A decrease in hepatitis C virus RNA to undetectable levels in chronic hepatitis C patients after PegIFNα + RVB or sofosbuvir + NS5A inhibitor treatment is associated with decreased insulin resistance and persistent oxidative stress

2020 ◽  
Vol 165 (12) ◽  
pp. 2759-2766 ◽  
Author(s):  
Allison Cázares-Cortazar ◽  
Luis A. Uribe-Noguez ◽  
José Antonio Mata-Marín ◽  
Jesús Gaytán-Martínez ◽  
María de la Luz Martínez-Rodríguez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Chronic Hepatitis C Patients ◽  
Inhibitor Treatment

scholarly journals Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level

Hepatology ◽  
1995 ◽  
Vol 22 (5) ◽  
pp. 1351-1354 ◽  
Author(s):  
Gotaro Yamada ◽  
Masahiro Takatani ◽  
Fumitoshi Kishi ◽  
Michiko Takahashi ◽  
Toshihiko Doi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alfa ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Chronic Hepatitis C Patients

scholarly journals Delayed Viral Clearance after 6-Week Treatment with Peginterferon Plus Ribavirin in a Patient with Chronic Hepatitis C Virus Genotype 1b

2016 ◽  
Vol 10 (2) ◽  
pp. 417-422 ◽  
Author(s):  
Akira Sato ◽  
Toshiya Ishii ◽  
Kayo Adachi ◽  
Hideaki Takahashi ◽  
Fumiaki Sano ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Virus Rna ◽  
Virus Genotype ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment. We report a case of clearance of chronic hepatitis C virus infection following early discontinuation (at 6 weeks) of peginterferon plus ribavirin therapy, without negativity for hepatitis C virus RNA during the treatment period. The patient was a 76-year-old Japanese male infected with hepatitis C virus genotype 1b and TT of IL28B rs8099917. Hepatitis C virus RNA remained positive at persistently low levels for more than 2 months after the cessation of therapy and became negative at 7 months after the discontinuation of therapy. Spontaneous clearance of hepatitis C virus RNA can occur following antiviral failure in patients with persistently low viral loads, and virological follow-up is therefore necessary in chronic hepatitis C virus infection, even after antiviral failure.

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