Chemical components separation with botulinum toxin A: a novel technique to improve primary fascial closure rates of the open abdomen

Hernia ◽  
2012 ◽  
Vol 17 (1) ◽  
pp. 101-107 ◽  
Author(s):  
M. D. Zielinski ◽  
N. Goussous ◽  
H. J. Schiller ◽  
D. Jenkins
Keyword(s):  
Botulinum Toxin ◽  
Open Abdomen ◽  
Botulinum Toxin A ◽  
Fascial Closure ◽  
Chemical Components ◽  
Toxin A ◽  
Components Separation ◽  
Novel Technique ◽  
Primary Fascial Closure

scholarly journals Chemical components separation with the use of Botulinum toxin A

2018 ◽  
Vol 97 (6) ◽  
pp. 569-573
Author(s):  
Gustavo Heluani Antunes de Mesquita ◽  
Yuri Justi Jardim ◽  
Diego Ramos Martines ◽  
Leando Ryuchi Iuamoto ◽  
Fernanda Nii ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Ventral Hernia ◽  
Botulinum Toxin A ◽  
Chemical Components ◽  
Toxin A ◽  
Components Separation ◽  
Para Determinar

Introdução: Hérnias ventrais são um resultado prevalente de cirurgias abdominais que podem representar um desafio cirúrgico em casos complexos, principalmente devido à tensão na musculatura da parede abdominal. A falha na correção cirúrgica pode levar a necessidade de um tratamento mais mórbido, além de um considerável impacto socioeconômico. Para que o risco de complicações seja menor, o uso da toxina botulínica A (TBA) pode ser uma alternativa pré-operatória para reduzir a tensão da parede abdominal, através de uma paralisia sustentada e reversível. Esta revisão crítica da literatura propõe avaliar o uso adjacente de TBA em correções de hérnias ventrais cirúrgicas. Métodos: Usando o banco de dados PubMed, as palavras-chave “ventral hernia” e “botullinum toxin” foram pesquisadas usando o operador “AND”. Os artigos foram selecionados com base em sua relevância e informações atualizadas. Os desfechos de interesse incluíram a mudança na largura do defeito da hérnia ventral e no comprimento do músculo da parede abdominal lateral, dor, recidiva de hérnia e complicações. Resultados: Foram encontrados 20 artigos de 2009 a 2018. Foram excluídos artigos devido à técnica irrelevante, uso de modelos animais e falta de dados sobre resultados. Redução da espessura da parede abdominal aumentando seu comprimento, menos dor perioperatória, redução de hérnia e correção com menos tensão foram observados após o uso da injeção de BTA. Nenhuma complicação ocorreu durante as aplicações. Conclusão: O uso de TBA parece ser uma alternativa promissora no manejo de hérnias ventrais devido à sua capacidade de reduzir a tensão na parede abdominal. No entanto, mais estudos são necessários para determinar a eficácia deste método.

scholarly journals P128 BOTULINUM TOXIN A IN CONJUNCTION WITH NEGATIVE PRESSURE WOUND THERAPY AND MESH-MEDIATED FASCIAL TRACTION PROVIDES HIGH RATE OF FASCIAL CLOSURE IN PATIENTS WITH OPEN ABDOMEN

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Irene Schmidt ◽  
Hans Friis Andersen ◽  
Nellie Zinther
Keyword(s):  
Botulinum Toxin ◽  
Open Abdomen ◽  
Botulinum Toxin A ◽  
Case Series ◽  
High Rate ◽  
Fascial Closure ◽  
Toxin A ◽  
Fascial Defect ◽  
The Mean

Abstract Aim Presentation of our data on Vacuum-Assisted Wound Closure and Permanent Onlay Mesh-Mediated Fascial Traction (VAWCPOM) in combination with Botulinum Toxin A (BTX-A) injection in the lateral abdominal wall as a treatment of the open abdomen (OA). Material and Methods This is a retrospective case series including patients treated for OA from January 2017 till March 2021 with VAWCPOM and BTX-A. Patient records were collected from medical charts, incl. age, sex, body mass index (BMI), comorbidity, initial fascial defect size, time until fascial closure, complications and, when available, outpatient follow-up. Results A total of 33 patients with OA were included. The mean age was 62,5 years, male/female ratio was 15:18, with a mean BMI of 35,4 kg/m2. The mean width of the fascial defect was 13,5 cm (5 - 25cm). The rate of fascial closure was 96,9%, achieved within a mean of 22,7 days. Fascial closure was not attainable in one patient who developed enterocutaneous fistula under treatment. 22 patients experienced in-hospital complications. Short-term follow-up was conducted in 22 patients, with hernia recurrences in three. Conclusions Treatment of OA remains a surgical challenge. This case series shows promising results with a high rate of fascial closure using a combination of VAWCPOM and BTX-A and an acceptable rate of postoperative complications in this severely challenging patient group. The rate of primary closure indicates that this may be the future management of open abdomen.

scholarly journals Chemical components separation with the use of botulinum toxin A: A critical review for correction of ventral hernia

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Yuri Justi Jardim ◽  
◽  
Gustavo Heluani Antunes de Mesquita ◽  
Leonardo Zumerkorn Pipek ◽  
Kayo Augusto de Almeida Medeiros ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Ventral Hernia ◽  
Critical Review ◽  
Botulinum Toxin A ◽  
Chemical Components ◽  
Toxin A ◽  
Components Separation

scholarly journals Fascial closure in giant ventral hernias after preoperative botulinum toxin a and progressive pneumoperitoneum: A systematic review and meta-analysis

Surgery ◽  
2021 ◽  
Author(s):  
Mathilde Maria Johanna van Rooijen ◽  
Yagmur Yurtkap ◽  
Mathias Allaeys ◽  
Nabeel Ibrahim ◽  
Frederik Berrevoet ◽  
...  
Keyword(s):  
Systematic Review ◽  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Meta Analysis ◽  
Fascial Closure ◽  
Toxin A ◽  
Ventral Hernias

1191: Bladder Botulinum Toxin a Injection Can Benefit Patients with Radiation and Chemical Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 393-393
Author(s):  
Yao-Chi Chuang ◽  
Yao-Chi Chuang ◽  
Dae Kyung Kim ◽  
Po-Hui Chiang ◽  
Michael B. Chancellor
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Toxin A

1125: Botulinum Toxin a in Neurogenic Bladder: Are there any Patient Predictors of Response?

2005 ◽  
Vol 173 (4S) ◽  
pp. 305-305
Author(s):  
Brigitte Schurch ◽  
Marianne de Seze ◽  
Pierre Denys ◽  
Emmanuel Chartier-Kastler ◽  
Francois Haab ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Neurogenic Bladder ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Predictors Of Response
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