scholarly journals Prevalence of the mitochondrial DNA A1555G mutation in sensorineural deafness patients in island Southeast Asia

2003 ◽  
Vol 48 (9) ◽  
pp. 480-483 ◽  
Author(s):  
Safarina G. Malik ◽  
Nova Pieter ◽  
Herawati Sudoyo ◽  
Abdul Kadir ◽  
Sangkot Marzuki
Antiquity ◽  
1989 ◽  
Vol 63 (240) ◽  
pp. 587-613 ◽  
Author(s):  
Matthew Spriggs

As with conventional definitions of the Neolithic anywhere, the concept in this region relies on there being an agricultural economy, the traces of which are largely indirect. These traces are artefacts interpreted as being linked to agriculture, rather than direct finds of agricultural crops, which are rare in Island Southeast Asia. This definition by artefacts is inevitably polythetic, particularly because many of the sites which have been investigated are hardly comparable. We can expect quite different assemblages from open village sites as opposed to special use sites such as burial caves, or frequentation caves that are used occasionally either by agriculturalists while hunting or by gatherer-hunter groups in some form of interaction with near-by agricultural populations. And rarely is a full range of these different classes of sites available in any one area.


2005 ◽  
Vol 114 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Tatsuo Matsunaga ◽  
Hiroshi Kumanomido ◽  
Yu-ichi Goto ◽  
Masae Shiroma ◽  
Shin-ichi Usami

To elucidate the pathophysiological and genetic mechanisms of hearing loss associated with the homoplasmic mitochondrial A1555G mutation in the absence of aminoglycoside exposure, we conducted audiological and genetic analyses on 67 maternally related members of a large Japanese family carrying this mutation. A consistent pattern was evident in the audiograms, with features of sensory presbycusis, cochlear origin at all levels of hearing loss, and a high degree of vulnerability of outer hair cells. That the degree of hearing loss was similar in affected subjects within the same sibling group but differed between sibling groups suggests the involvement of nuclear modifier genes. Total mitochondrial DNA sequences were completely identical among subjects with various levels of hearing loss, and lacked additional pathogenic mutations. For the diagnosis of sensorineural hearing loss, the mitochondrial A1555G mutation should be considered when these features are present even in the absence of aminoglycoside exposure.


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