Characteristic endoscopic findings of gastric adenocarcinoma of fundic-gland mucosa type

2021 ◽  
Author(s):  
Kentaro Imamura ◽  
Kenshi Yao ◽  
Satoshi Nimura ◽  
Hiroshi Tanabe ◽  
Takao Kanemitsu ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Fundic Gland ◽  
Endoscopic Findings

scholarly journals Influence ofHelicobacter pyloriInfection on Endoscopic Findings of Gastric Adenocarcinoma of the Fundic Gland Type

2019 ◽  
Vol 19 (2) ◽  
pp. 225
Author(s):  
Fumiaki Ishibashi ◽  
Keita Fukushima ◽  
Takashi Ito ◽  
Konomi Kobayashi ◽  
Ryu Tanaka ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Fundic Gland ◽  
Endoscopic Findings ◽  
Gland Type

scholarly journals Clinicopathological and Endoscopic Features of Raspberry-Shaped Gastric Cancer in Helicobacter pylori-Uninfected Patients

Digestion ◽  
2020 ◽  
pp. 1-8
Author(s):  
Noboru Yatagai ◽  
Hiroya Ueyama ◽  
Muneo Ikemura ◽  
Ryota Uchida ◽  
Hisanori Utsunomiya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Adenocarcinoma ◽  
Submucosal Tumor ◽  
Clinicopathological Characteristics ◽  
Fundic Gland ◽  
Histopathological Classification ◽  
Histological Characteristics ◽  
Greater Curvature ◽  
H Pylori ◽  
Tumor Shape

<b><i>Background:</i></b> Gastric adenocarcinoma of foveolar type (GA-FV) is a raspberry-shaped gastric cancer (RSGC) and garners much attention as <i>H. pylori</i> (<i>Hp</i>)-uninfected gastric cancer. However, the classification and clinicopathological and endoscopic features of RSGCs in <i>Hp</i>-uninfected patients are poorly defined. We designed a new histopathological classification of RSGC and compared them via endoscopic and clinicopathological characteristics. <b><i>Summary:</i></b> From 996 patients with early gastric cancers resected by endoscopy in our hospital, we studied 24 RSGC lesions from 21 (2.4%) <i>Hp</i>-uninfected patients. RSGCs were classified into 3 histological types as follows: GA-FV (<i>n</i> = 19), gastric adenocarcinoma of fundic gland type (GA-FG, <i>n</i> = 2), and gastric adenocarcinoma of fundic gland mucosa type (GA-FGM, <i>n</i> = 3). Most of the lesions were found at the greater curvature of the upper or middle third of the stomach. GA-FV lesions were homogeneously reddish and frequently accompanied with a whitish area around the tumor and an irregular microvascular (MV) pattern; these features were confirmed histopathologically by the presence of homogeneous neoplastic foveolar epithelium with foveolar hyperplasia around the tumors. GA-FG lesions might be heterogeneously reddish with a submucosal tumor shape and regular MV pattern; these were confirmed by the presence of covered or mixed nonneoplastic epithelium on deeper regions of tumors. GA-FGM lesions might be homogeneously reddish and occasionally had a submucosal tumor shape and irregular MV pattern; these were confirmed by the presence of homogeneous neoplastic foveolar epithelium on deeper regions of the tumors. <b><i>Key Messages:</i></b> RSGCs in <i>Hp</i>-uninfected patients are classified into 3 histopathological types. For accurate diagnosis of RSGCs, it may be necessary to fully understand endoscopic features of these lesions based on these histological characteristics and to take a precise biopsy.

scholarly journals Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands

2017 ◽  
Vol 23 (38) ◽  
pp. 7047-7053 ◽  
Author(s):  
Shigeo Manabe ◽  
Ken-ichi Mukaisho ◽  
Takayuki Yasuoka ◽  
Fumitaka Usui ◽  
Tatsuzo Matsuyama ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Fundic Gland ◽  
Gastric Glands ◽  
Gland Type

Histopathologic Change of a Case of Gastric Oxyntic Neoplasm (Gastric Adenocarcinoma of Fundic Gland Mucosa Type) Through 5 Years With Concurrent Other Oxyntic Gland Lesions

2020 ◽  
pp. 106689692096257
Author(s):  
Yoko Sato ◽  
Taiki Sato ◽  
Jun Matsushima ◽  
Akiko Fujii ◽  
Yuko Ono ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Chief Cell ◽  
Fundic Gland ◽  
Submucosal Dissection ◽  
Epithelial Neoplasms ◽  
Oxyntic Gland ◽  
Gland Type ◽  
Histological Progression

Some gastric epithelial neoplasms show predominant chief cell differentiation (oxyntic gland neoplasms), in which the entity of “gastric adenocarcinoma of fundic gland type” was firstly designated, whereas a possible more aggressive subgroup “gastric adenocarcinoma of fundic gland mucosa type” (GA-FGM) was subsequently proposed. However, the histopathologic progression mode of these neoplasms has not been sufficiently reported. In this article, we describe a case of GA-FGM in which we could observe its progression during 5 years. The tumor was removed by endoscopic submucosal dissection 5 years after the first biopsy, which had already shown a feature of oxyntic gland neoplasm. During the follow-up period, the endoscopy revealed little change in the tumor appearance. However, the histology of endoscopic submucosal dissection showed submucosal extension with its histological progression. Besides, other oxyntic gland neoplasms of the stomach were observed metachronously or synchronously, giving an implication about a common pathogenetic basis of these lesions.

Gastric Adenocarcinoma Arising from Fundic Gland Polyps in a Patient with Familial Adenomatous Polyposis Syndrome

2008 ◽  
Vol 74 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Sean Garrean ◽  
Justin Hering ◽  
Abdul Saied ◽  
Jigna Jani ◽  
N. Joseph Espat
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Gastric Adenocarcinoma ◽  
Intestinal Tract ◽  
Treatment Strategies ◽  
Colorectal Polyps ◽  
Fundic Gland ◽  
Adenomatous Polyposis ◽  
Disease Manifestation ◽  
Fundic Gland Polyps ◽  
Optimal Screening

Familial adenomatous polyposis (FAP) is a rare hereditary syndrome characterized by multiple colorectal polyps and early development of colorectal cancer. Although FAP uniformly involves the large bowel, it may also produce lesions in the stomach and upper intestinal tract. Fundic gland polyps are the most common gastric lesion in FAP. In the general population, these polyps are considered benign and have no malignant potential. However, in FAP patients, fundic gland polyps have been occasionally recognized as precursor lesions from which invasive cancer may develop. Herein, we present a case of gastric adenocarcinoma arising from fundic gland polyps in an FAP patient. We also review reported cases of gastric cancer in FAP and FAP variant patients in an effort to better understand the pathology, clinical course, and optimal screening and treatment strategies for this disease manifestation.

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