Renal stones in patients with autosomal dominant polycystic kidney disease, a treatment challenge?

Patients with autosomal dominant polycystic kidney disease become symptomatic and are diagnosed usually at adulthood. The rate of nephrolithiasis in these patients is 5–10 times the rate in the general population, and both anatomic and metabolic abnormalities play role in the formation of renal stones. However, nephrolithiasis is rare in childhood age group. In this paper, an 11-year-old child with autosomal dominant polycystic kidney disease presenting with nephrolithiasis is discussed.

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Percutaneous Nephrolithotomy under Ultrasound Guidance in Patients with Renal Calculi and Autosomal Dominant Polycystic Kidney Disease: A Report of 11 Cases

Advances in Urology ◽

10.1155/2017/3483172 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Xiao Wang ◽

Xuecheng Yang ◽

Xiulong Zhong ◽

Zhenlin Wang ◽

Senyao Xue ◽

...

Keyword(s):

Kidney Disease ◽

Polycystic Kidney Disease ◽

Percutaneous Nephrolithotomy ◽

Ultrasound Guidance ◽

Autosomal Dominant ◽

Renal Stones ◽

Renal Calculi ◽

Lateral Position ◽

Polycystic Kidney ◽

Autosomal Dominant Polycystic Kidney

Nephrolithiasis accelerates the renal failure in the patients with ADPKD. In order to evaluate the role of percutaneous nephrolithotomy in management of calculus in these patients, 11 patients with autosomal dominant polycystic kidney disease and renal stones were included in the study. Two patients had bilateral renal stones. All patients were treated by percutaneous nephrolithotomy under ultrasound guidance. 13 percutaneous nephrolithotomy procedures were performed in 1 stage by the urology team under ultrasound guidance. 5 people received second operation with flexible nephroscopy in lateral position. The success rate and morbidity and mortality of the technique and hospital stay were recorded.Results. The puncture procedure was fully successful in all cases. The renal function improved in these patients. 5 patients had moderate fever after the surgery. 5 patients received flexible nephroscopy to take out the residual calculi. 2 persons had ESWL therapy after the surgery.Conclusion. PCNL is an ideal, safe, and effective method to remove the stones from those patients with no definite increase in the risk of complication. The outcome and stone-free rate are satisfactory comparable to the PCNL in the patients without ADPKD.

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Calcified Renal Stones and Cyst Calcifications in Autosomal Dominant Polycystic Kidney Disease: Clinical and CT Study in 84 Patients

Journal of Diagnostic Medical Sonography ◽

10.1177/875647939200800517 ◽

1992 ◽

Vol 8 (5) ◽

pp. 282-282

Keyword(s):

Kidney Disease ◽

Polycystic Kidney Disease ◽

Autosomal Dominant ◽

Renal Stones ◽

Polycystic Kidney ◽

Autosomal Dominant Polycystic Kidney

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Calcified renal stones and cyst calcifications in autosomal dominant polycystic kidney disease: clinical and CT study in 84 patients.

American Journal of Roentgenology ◽

10.2214/ajr.159.1.1609726 ◽

1992 ◽

Vol 159 (1) ◽

pp. 77-81 ◽

Cited By ~ 41

Author(s):

E Levine ◽

J J Grantham

Keyword(s):

Kidney Disease ◽

Polycystic Kidney Disease ◽

Autosomal Dominant ◽

Renal Stones ◽

Polycystic Kidney ◽

Autosomal Dominant Polycystic Kidney

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Association between Nephrolithiasis, Hypertension and Obesity in Polycystic Kidney Disease

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.010 ◽

2015 ◽

Vol 4 (1) ◽

pp. 43-46 ◽

Cited By ~ 4

Author(s):

Valbona Bajrami ◽

Alma Idrizi ◽

Enver Roshi ◽

Myftar Barbullushi

Keyword(s):

Blood Pressure ◽

Kidney Disease ◽

Diastolic Blood Pressure ◽

Polycystic Kidney Disease ◽

Autosomal Dominant ◽

Total Cholesterol Level ◽

Renal Stones ◽

Polycystic Kidney ◽

Metabolic Evaluation ◽

Autosomal Dominant Polycystic Kidney

AIM: We aim to define the correlations between nephrolithiasis, hypertension, age and obesity in patients with autosomal dominant polycystic kidney disease (ADPKD) in Albania. MATERIAL AND METHODS: We included 100 patients with autosomal dominant polycystic kidney from 2011 to 2014. The patients underwent X-ray and renal ultrasonography. We performed the metabolic evaluation of blood and urine.RESULTS: The patients with renal stones had a higher level of mean systolic and diastolic blood pressure compared with patients without stones (155 ± 12 mmHg vs. 145 ± 8 mmHg, and 105 ± 0.9 mmHg vs. 92 ± 1.28 mmHg, respectively). Patients with renal stones were older (47 ± 15 vs. 38 ± 5 years), had a higher prevalence of obesity [body mass index (BMI): 28 ± 2.4 vs. 25.7 ± 0.6], had higher levels of total cholesterol level (220 ± 5 mg/dl vs. 203 ± 4 mg/dl) as well as triglyceride levels (160 ± 9 mg/dl vs. 126 ± 4 mg/dl), compared with no renal stone individuals. CONCLUSION: ADPKD patients with renal stones in our study had a higher mean level of systolic and diastolic blood pressure, BMI and cholesterol and triglycerides levels compared with individuals without renal stones.

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