scholarly journals The role of the alternative pathway of complement activation in glomerular diseases

2018 ◽  
Vol 18 (3) ◽  
pp. 297-318 ◽  
Author(s):  
Emilia Łukawska ◽  
Magdalena Polcyn-Adamczak ◽  
Zofia I. Niemir
Keyword(s):  
Complement Activation ◽  
Alternative Pathway ◽  
Glomerular Diseases ◽  
Alternative Pathway Of Complement

scholarly journals Role of Complement in Protection against Cryptococcus gattii Infection

2008 ◽  
Vol 77 (3) ◽  
pp. 1061-1070 ◽  
Author(s):  
Kileen L. Mershon ◽  
Alex Vasuthasawat ◽  
Gregory W. Lawson ◽  
Sherie L. Morrison ◽  
David O. Beenhouwer
Keyword(s):  
Complement Activation ◽  
Alternative Pathway ◽  
Complement Pathway ◽  
Wild Type ◽  
Complement Components ◽  
Factor B ◽  
Alternative Pathway Of Complement ◽  
Deficient Mice

ABSTRACT Previous studies have shown that the alternative pathway of complement activation plays an important role in protection against infection with Cryptococcus neoformans. Cryptococcus gattii does not activate the alternative pathway as well as C. neoformans in vitro. The role of complement in C. gattii infection in vivo has not been reported. In this study, we used mice deficient in complement components to investigate the role of complement in protection against a C. gattii isolate from an ongoing outbreak in northwestern North America. While factor B-deficient mice showed an enhanced rate of death, complement component C3-deficient mice died even more rapidly, indicating that the alternative pathway was not the only complement pathway contributing to protection against disease. Both C3- and factor B-deficient mice had increased fungal burdens in comparison to wild-type mice. Histopathology revealed an overwhelming fungal burden in the lungs of these complement-deficient mice, which undoubtedly prevented efficient gas exchange, causing death. Following the fate of radiolabeled organisms showed that both factor B- and C3-deficient mice were less effective than wild-type mice in clearing organisms. However, opsonization of C. gattii with complement components was not sufficient to prolong life in mice deficient in complement. Killing of C. gattii by macrophages in vitro was decreased in the presence of serum from factor B- and C3-deficient versus wild-type mice. In conclusion, we have demonstrated that complement activation is crucial for survival in C. gattii infection. Additionally, we have shown that the alternative pathway of complement activation is not the only complement pathway contributing to protection.

A reexamination of the role of magnesium in the human alternative pathway of complement

1986 ◽  
Vol 23 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Edward L.G. Pryzdial ◽  
David E. Isenman
Keyword(s):  
Alternative Pathway ◽  
Alternative Pathway Of Complement

scholarly journals The Alternative Pathway of Complement Activation in the Neonate

1975 ◽  
Vol 9 (10) ◽  
pp. 803-806 ◽  
Author(s):  
Peter A Feinstein ◽  
Stephen R Kaplan
Keyword(s):  
Complement Activation ◽  
Alternative Pathway ◽  
Alternative Pathway Of Complement

ROLE OF THE ALTERNATIVE PATHWAY IN THE EARLY COMPLEMENT ACTIVATION FOLLOWING MAJOR TRAUMA

Shock ◽  
2007 ◽  
Vol 28 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Michael T. Ganter ◽  
Karim Brohi ◽  
Mitchell J. Cohen ◽  
Lisa A. Shaffer ◽  
Mary C. Walsh ◽  
...  
Keyword(s):  
Complement Activation ◽  
Major Trauma ◽  
Alternative Pathway

scholarly journals Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H

2006 ◽  
Vol 177 (3) ◽  
pp. 1872-1878 ◽  
Author(s):  
Nalini S. Bora ◽  
Sankaranarayanan Kaliappan ◽  
Purushottam Jha ◽  
Qin Xu ◽  
Jeong-Hyeon Sohn ◽  
...  
Keyword(s):  
Choroidal Neovascularization ◽  
Complement Activation ◽  
Alternative Pathway ◽  
Factor H ◽  
Factor B

scholarly journals Alternative Pathway of Complement Activation in Full Term and Premature Infants

1979 ◽  
Vol 13 (5) ◽  
pp. 641-643 ◽  
Author(s):  
Robert C Strunk ◽  
Lawrence J Fenton ◽  
John A Gaines
Keyword(s):  
Premature Infants ◽  
Complement Activation ◽  
Alternative Pathway ◽  
Full Term ◽  
Alternative Pathway Of Complement
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