Identification of a major human serum DNA-binding protein as β1H of the alternative pathway of complement activation

1980 ◽  
Vol 94 (1) ◽  
pp. 61-67 ◽  
Author(s):  
William D. Gardner ◽  
Philip J. White ◽  
Sallie O. Hoch
Keyword(s):  
Dna Binding ◽  
Human Serum ◽  
Complement Activation ◽  
Binding Protein ◽  
Alternative Pathway ◽  
Dna Binding Protein ◽  
Alternative Pathway Of Complement ◽  
Serum Dna

scholarly journals A serum DNA-binding protein absent in malignant disease

FEBS Letters ◽  
1978 ◽  
Vol 92 (2) ◽  
pp. 211-213 ◽  
Author(s):  
J.G. Lewis ◽  
C.M. André
Keyword(s):  
Dna Binding ◽  
Malignant Disease ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Serum Dna

scholarly journals Studies on neutralization of human serum bactericidal activity by sodium amylosulfate

1977 ◽  
Vol 6 (2) ◽  
pp. 128-131
Author(s):  
W H Traub
Keyword(s):  
Human Serum ◽  
Bactericidal Activity ◽  
Complement Activation ◽  
Alternative Pathway ◽  
Magnesium Ions ◽  
Tetraacetic Acid ◽  
Blood Samples ◽  
Serum Bactericidal Activity ◽  
Alternative Pathway Of Complement

The synthetic anticoagulant sodium amylosulfate (SAS) at concentrations of 125 to 2,000 microgram/ml failed to completely neutralize the bactericidal activity of 80 and 50% (by volume) fresh human serum. Furthermore, SAS failed to inhibit the alternative pathway of complement activation in 80% (by volume) fresh human serum that had been chelated with 0.01 M magnesium ions plus 0.01 M ethyleneglycol-bis(beta-aminoethylether)-N,N-tetraacetic acid. However, SAS at 250 to 1,000 microgram/ml effectively neutralized the bactericidal activity of 20% (by volume) fresh human serum. Therefore, SAS (at 250 to 1,000 microgram/ml) should be used only in blood samples that have been diluted at least fivefold (less than or equal to 20% [by volume]) in suitable broth media.

The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell lines

2010 ◽  
Vol 222 (03) ◽  
Author(s):  
S Degen ◽  
S Kuhfittig-Kulle ◽  
JH Schulte ◽  
F Westermann ◽  
A Schramm ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cell Lines ◽  
Binding Protein ◽  
Neuroblastoma Cell ◽  
Dna Binding Protein ◽  
Neuroblastoma Cell Lines
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