Rapid Quality Assessment of Nonrigid Image Registration Based on Supervised Learning

Author(s):  
Eung-Joo Lee ◽  
William Plishker ◽  
Nobuhiko Hata ◽  
Paul B. Shyn ◽  
Stuart G. Silverman ◽  
...  
Neurosurgery ◽  
2015 ◽  
Vol 76 (6) ◽  
pp. 756-765 ◽  
Author(s):  
Srivatsan Pallavaram ◽  
Pierre-François D'Haese ◽  
Wendell Lake ◽  
Peter E. Konrad ◽  
Benoit M. Dawant ◽  
...  

Abstract BACKGROUND: Finding the optimal location for the implantation of the electrode in deep brain stimulation (DBS) surgery is crucial for maximizing the therapeutic benefit to the patient. Such targeting is challenging for several reasons, including anatomic variability between patients as well as the lack of consensus about the location of the optimal target. OBJECTIVE: To compare the performance of popular manual targeting methods against a fully automatic nonrigid image registration-based approach. METHODS: In 71 Parkinson disease subthalamic nucleus (STN)-DBS implantations, an experienced functional neurosurgeon selected the target manually using 3 different approaches: indirect targeting using standard stereotactic coordinates, direct targeting based on the patient magnetic resonance imaging, and indirect targeting relative to the red nucleus. Targets were also automatically predicted by using a leave-one-out approach to populate the CranialVault atlas with the use of nonrigid image registration. The different targeting methods were compared against the location of the final active contact, determined through iterative clinical programming in each individual patient. RESULTS: Targeting by using standard stereotactic coordinates corresponding to the center of the motor territory of the STN had the largest targeting error (3.69 mm), followed by direct targeting (3.44 mm), average stereotactic coordinates of active contacts from this study (3.02 mm), red nucleus-based targeting (2.75 mm), and nonrigid image registration-based automatic predictions using the CranialVault atlas (2.70 mm). The CranialVault atlas method had statistically smaller variance than all manual approaches. CONCLUSION: Fully automatic targeting based on nonrigid image registration with the use of the CranialVault atlas is as accurate and more precise than popular manual methods for STN-DBS.


2013 ◽  
Vol 22 (12) ◽  
pp. 4905-4917 ◽  
Author(s):  
Wei Sun ◽  
Wiro J. Niessen ◽  
Marijn van Stralen ◽  
Stefan Klein

2014 ◽  
Vol 18 (2) ◽  
pp. 343-358 ◽  
Author(s):  
Hassan Rivaz ◽  
Zahra Karimaghaloo ◽  
D. Louis Collins

2021 ◽  
Author(s):  
◽  
Mouna Hakami

<p><b>This thesis presents two studies on non-intrusive speech quality assessment methods. The first applies supervised learning methods to speech quality assessment, which is a common approach in machine learning based quality assessment. To outperform existing methods, we concentrate on enhancing the feature set. In the second study, we analyse quality assessment from a different point of view inspired by the biological brain and present the first unsupervised learning based non-intrusive quality assessment that removes the need for labelled training data.</b></p> <p>Supervised learning based, non-intrusive quality predictors generally involve the development of a regressor that maps signal features to a representation of perceived quality. The performance of the predictor largely depends on 1) how sensitive the features are to the different types of distortion, and 2) how well the model learns the relation between the features and the quality score. We improve the performance of the quality estimation by enhancing the feature set and using a contemporary machine learning model that fits this objective. We propose an augmented feature set that includes raw features that are presumably redundant. The speech quality assessment system benefits from this redundancy as it results in reducing the impact of unwanted noise in the input. Feature set augmentation generally leads to the inclusion of features that have non-smooth distributions. We introduce a new pre-processing method and re-distribute the features to facilitate the training. The evaluation of the system on the ITU-T Supplement23 database illustrates that the proposed system outperforms the popular standards and contemporary methods in the literature.</p> <p>The unsupervised learning quality assessment approach presented in this thesis is based on a model that is learnt from clean speech signals. Consequently, it does not need to learn the statistics of any corruption that exists in the degraded speech signals and is trained only with unlabelled clean speech samples. The quality has a new definition, which is based on the divergence between 1) the distribution of the spectrograms of test signals, and 2) the pre-existing model that represents the distribution of the spectrograms of good quality speech. The distribution of the spectrogram of the speech is complex, and hence comparing them is not trivial. To tackle this problem, we propose to map the spectrograms of speech signals to a simple latent space.</p> <p>Generative models that map simple latent distributions into complex distributions are excellent platforms for our work. Generative models that are trained on the spectrograms of clean speech signals learned to map the latent variable $Z$ from a simple distribution $P_Z$ into a spectrogram $X$ from the distribution of good quality speech.</p> <p>Consequently, an inference model is developed by inverting the pre-trained generator, which maps spectrograms of the signal under the test, $X_t$, into its relevant latent variable, $Z_t$, in the latent space. We postulate the divergence between the distribution of the latent variable and the prior distribution $P_Z$ is a good measure of the quality of speech.</p> <p>Generative adversarial nets (GAN) are an effective training method and work well in this application. The proposed system is a novel application for a GAN. The experimental results with the TIMIT and NOIZEUS databases show that the proposed measure correlates positively with the objective quality scores.</p>


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