Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

2014 ◽  
Vol 43 (1) ◽  
pp. 94-106 ◽  
Author(s):  
Lucas H. Timmins ◽  
David S. Molony ◽  
Parham Eshtehardi ◽  
Michael C. McDaniel ◽  
John N. Oshinski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Disease Progression ◽  
Wall Shear ◽  
Artery Disease ◽  
Coronary Artery Disease Progression

scholarly journals HIGHER CORONARY WALL SHEAR STRESS IS ASSOCIATED WITH GREATER IMPAIRMENT IN MICROVASCULAR FUNCTION IN PATIENTS WITH NON–OBSTRUCTIVE CORONARY ARTERY DISEASE

2013 ◽  
Vol 61 (10) ◽  
pp. E1843
Author(s):  
Parham Eshtehardi ◽  
Michel T Corban ◽  
Jin Suo ◽  
Marina Piccinelli ◽  
Lucas H Timmins ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Obstructive Coronary Artery Disease ◽  
Microvascular Function ◽  
Coronary Wall ◽  
Wall Shear ◽  
Artery Disease

scholarly journals Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease

2017 ◽  
Vol 14 (127) ◽  
pp. 20160972 ◽  
Author(s):  
Lucas H. Timmins ◽  
David S. Molony ◽  
Parham Eshtehardi ◽  
Michael C. McDaniel ◽  
John N. Oshinski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Necrotic Core ◽  
Atherosclerosis Progression ◽  
Plaque Area ◽  
Wall Shear ◽  
Artery Disease ◽  
Total Plaque Area

Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of this investigation was to examine the association between oscillatory WSS, in combination with WSS magnitude, and coronary atherosclerosis progression. We hypothesized that regions of low and oscillatory WSS will demonstrate progression towards more vulnerable lesions, while regions exposed to low and non-oscillatory WSS will exhibit progression towards more stable lesions. Patients ( n = 20) with non-flow-limiting coronary artery disease (CAD) underwent baseline and six-month follow-up angiography, Doppler velocity and radiofrequency intravascular ultrasound (VH-IVUS) acquisition. Computational fluid dynamics models were constructed to compute time-averaged WSS magnitude and oscillatory WSS. Changes in VH-IVUS-defined total plaque and constituent areas were quantified in focal regions (i.e. sectors; n = 14 235) and compared across haemodynamic categories. Compared with sectors exposed to low WSS magnitude, high WSS sectors demonstrated regression of total plaque area ( p < 0.001) and fibrous tissue ( p < 0.001), and similar progression of necrotic core. Sectors subjected to low and oscillatory WSS exhibited total plaque area regression, while low and non-oscillatory WSS sectors demonstrated total plaque progression ( p < 0.001). Furthermore, compared with low and non-oscillatory WSS areas, sectors exposed to low and oscillatory WSS demonstrated regression of fibrous ( p < 0.001) and fibrofatty ( p < 0.001) tissue and similar progression of necrotic core ( p = 0.82) and dense calcium ( p = 0.40). Herein, we demonstrate that, in patients with non-obstructive CAD, sectors subjected to low and oscillatory WSS demonstrated regression of total plaque, fibrous and fibrofatty tissue, and progression of necrotic core and dense calcium, which suggest a transformation to a more vulnerable phenotype.

scholarly journals Association of Coronary Wall Shear Stress With Atherosclerotic Plaque Burden, Composition, and Distribution in Patients With Coronary Artery Disease

2012 ◽  
Vol 1 (4) ◽  
Author(s):  
Parham Eshtehardi ◽  
Michael C. McDaniel ◽  
Jin Suo ◽  
Saurabh S. Dhawan ◽  
Lucas H. Timmins ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Atherosclerotic Plaque ◽  
Plaque Burden ◽  
Coronary Wall ◽  
Wall Shear ◽  
Artery Disease

scholarly journals Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease

2018 ◽  
Vol 11 (20) ◽  
pp. 2072-2080 ◽  
Author(s):  
Arnav Kumar ◽  
Olivia Y. Hung ◽  
Marina Piccinelli ◽  
Parham Eshtehardi ◽  
Michel T. Corban ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Wall Shear Stress ◽  
Coronary Wall ◽  
Nonobstructive Coronary Artery Disease ◽  
Wall Shear ◽  
Artery Disease

Development of Framework to Examine the Focal Association Between Wall Shear Stress and Coronary Artery Disease Progression in the Clinical Setting

2013 ◽  
Author(s):  
Lucas H. Timmins ◽  
David S. Molony ◽  
Parham Eshtehardi ◽  
Michael C. McDaniel ◽  
John N. Oshinski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Plaque Progression ◽  
Clinical Investigations ◽  
Coronary Lesions ◽  
Wall Shear ◽  
Coronary Events ◽  
Artery Disease

Natural history data on clinical coronary artery disease (CAD) indicates that there is a critical need to prospectively identify rapidly progressing and vulnerable coronary lesions that may cause potentially fatal acute coronary events [1]. Recent prospective clinical investigations have evaluated the value of wall shear stress (WSS) as a prognostic marker for identifying rapidly progressing coronary lesions [2,3]. Data indicate that low WSS is associated with significant plaque progression, while regions of high WSS are associated with plaque regression and phenotypic transformation towards a more vulnerable lesion. While these studies provided unprecedented data on the role of hemodynamic-induced mechanical forces in lesion dynamics, they were limited by a lack of focal understanding of the association between WSS and plaque progression. Specifically, despite the understanding that WSS and plaque progression are heterogeneous around the artery’s circumference, in each image slice WSS values were spatially averaged around the circumference and correlated with average values for changes in virtual histology-intravascular ultrasound (VH-IVUS) defined plaque constituent areas.

scholarly journals Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease

Circulation ◽  
2011 ◽  
Vol 124 (7) ◽  
pp. 779-788 ◽  
Author(s):  
Habib Samady ◽  
Parham Eshtehardi ◽  
Michael C. McDaniel ◽  
Jin Suo ◽  
Saurabh S. Dhawan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Atherosclerotic Plaque ◽  
Arterial Remodeling ◽  
Artery Wall ◽  
Coronary Artery Wall ◽  
Wall Shear ◽  
Artery Disease
Sign in / Sign up

Export Citation Format

Share Document