Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer

2015 ◽  
Vol 150 (3) ◽  
pp. 479-486 ◽  
Author(s):  
X. Zhu ◽  
L. Shan ◽  
F. Wang ◽  
J. Wang ◽  
F. Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative ◽  
Prognostic Biomarker ◽  
Brca1 Gene

scholarly journals CBP/β-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer

Cancers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 525 ◽  
Author(s):  
Alexander Ring ◽  
Cu Nguyen ◽  
Goar Smbatyan ◽  
Debu Tripathy ◽  
Min Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Drug Resistance ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative ◽  
Creb Binding Protein ◽  
Novel Therapeutic

Background: Triple negative breast cancers (TNBCs) are an aggressive BC subtype, characterized by high rates of drug resistance and a high proportion of cancer stem cells (CSC). CSCs are thought to be responsible for tumor initiation and drug resistance. cAMP-response element-binding (CREB) binding protein (CREBBP or CBP) has been implicated in CSC biology and may provide a novel therapeutic target in TNBC. Methods: RNA Seq pre- and post treatment with the CBP-binding small molecule ICG-001 was used to characterize CBP-driven gene expression in TNBC cells. In vitro and in vivo TNBC models were used to determine the therapeutic effect of CBP inhibition via ICG-001. Tissue microarrays (TMAs) were used to investigate the potential of CBP and associated proteins as biomarkers in TNBC. Results: The CBP/ß-catenin/FOXM1 transcriptional complex drives gene expression in TNBC and is associated with increased CSC numbers, drug resistance and poor survival outcome. Targeting of CBP/β-catenin/FOXM1 with ICG-001 eliminated CSCs and sensitized TNBC tumors to chemotherapy. Immunohistochemistry of TMAs demonstrated a significant correlation between FOXM1 expression and TNBC subtype. Conclusion: CBP/β-catenin/FOXM1 transcriptional activity plays an important role in TNBC drug resistance and CSC phenotype. CBP/β-catenin/FOXM1 provides a molecular target for precision therapy in triple negative breast cancer and could form a rationale for potential clinical trials.

scholarly journals The long non-coding RNA ADAMTS9-AS2 was identified as a potential prognostic biomarker in triple-negative breast cancer

2020 ◽  
Vol 6 (3) ◽  
pp. 16215-16226
Author(s):  
Daniel Rodrigues Bastos ◽  
Jean Michel Rocha Sampaio Leite ◽  
Mércia Patrícia Ferreira Conceição ◽  
Cesar Augusto Sam Tiago Vilanova-Costa ◽  
Antonio Márcio Teodoro Cordeiro Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Prognostic Biomarker ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals RSK2: a promising therapeutic target for the treatment of triple-negative breast cancer

2019 ◽  
Vol 24 (1) ◽  
pp. 1-5 ◽  
Author(s):  
My-my Huynh ◽  
Aarthi Jayanthan ◽  
Mary Rose Pambid ◽  
Gerrit Los ◽  
Sandra E. Dunn
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative ◽  
Promising Therapeutic Target

c-Met as a potential therapeutic target in triple negative breast cancer

2020 ◽  
pp. 295-326
Author(s):  
Sapana Sameer Chaudhary ◽  
Sameer Choudhary ◽  
Sakshi Rawat ◽  
Gouri Ahir ◽  
Anwar L. Bilgrami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative ◽  
Potential Therapeutic Target

scholarly journals CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead

2018 ◽  
Vol 5 (4) ◽  
pp. e1481814
Author(s):  
Eldad Zacksenhaus ◽  
Jeff C. Liu ◽  
Letizia Granieri ◽  
Ioulia Vorobieva ◽  
Dong-Yu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative

Abstract P6-03-11: Erk5 as a therapeutic target in triple negative breast cancer (TNBC)

2015 ◽  
Author(s):  
Mariska Sauzine Miranda ◽  
Fares Al Ejeh ◽  
Wei Shi ◽  
Peter Simpson ◽  
Sunil Lakhani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Triple Negative
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