scholarly journals Hypothermic machine perfusion after static cold storage improves ovarian function in rat ovarian tissue transplantation

2020 ◽  
Vol 37 (7) ◽  
pp. 1745-1753
Author(s):  
Shichen Zhang ◽  
Hanlin Yao ◽  
Yang Liu ◽  
Lian Ren ◽  
Du Xiang ◽  
...  
Keyword(s):  
Cold Storage ◽  
Ovarian Function ◽  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Machine Perfusion ◽  
Ovarian Tissue Transplantation ◽  
Hypothermic Machine Perfusion

scholarly journals Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Sepideh Sheshpari ◽  
Mahnaz Shahnazi ◽  
Halimeh Mobarak ◽  
Shahin Ahmadian ◽  
Alberto Miranda Bedate ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Function ◽  
Current Knowledge ◽  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Endocrine Function ◽  
Cochrane Library ◽  
Reproductive Outcome ◽  
Follicular Growth ◽  
Ovarian Tissue Transplantation

AbstractThe aim of this systematic review study is to summarize the current knowledge of ovarian tissue transplantation and provide insight on ovarian function, fertility and reproductive outcome following ovarian tissue transplantation. Relevant studies were identified by searching through PubMed, Cochrane Library, Embase, ProQuest, and Scopus databases until August 2018. Ovarian function by examination of the hormonal level was evaluated, together with follicular growth, the return of menstrual cycle and assessment of reproductive consequences: pregnancy, miscarriage rates and live birth after transplantation. Studies including female patients aged between 22 and 49 years that were subjected to ovarian tissue transplantation were considered. A total of 1185 studies were identified in the primary search. Titles and abstracts were screened for assessment of the inclusion criteria. Finally, twenty-five articles met the criteria and were included in this study. In general, 70% of patients that underwent ovarian tissue transplantation had ovarian and endocrine function restoration as well as follicular growth. Pregnancy was reported with 52% of the patients. The available evidence suggests that ovarian tissue transplantation is a useful and an applied approach to restore hormonal function, endocrine balance and eventually fertility outcomes in patients that are predisposed to lose their fertility, diagnosed with premature ovarian failure (POF), as well as women undergoing cancer treatments. Identification of the techniques with the lowest invasions for follicular and oocyte development after ovarian tissue transplantation aiming to reduce probable adverse effects after treatment is indispensable.

scholarly journals Expectations and limitations of ovarian tissue transplantation

Zygote ◽  
2017 ◽  
Vol 25 (4) ◽  
pp. 391-403 ◽  
Author(s):  
N.J. Donfack ◽  
K.A. Alves ◽  
V.R. Araújo ◽  
A. Cordova ◽  
J.R. Figueiredo ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Function ◽  
Ex Vivo ◽  
Ovarian Tissue ◽  
Ovarian Failure ◽  
Tissue Transplantation ◽  
Endocrine Function ◽  
Embryo Cryopreservation ◽  
Pelvic Cavity ◽  
Ovarian Tissue Transplantation

SummaryConstant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation. However, for children or prepubertal women needing immediate chemotherapy, cryopreservation of ovarian tissue is the only alternative. The ultimate aim of this strategy is to implant ovarian tissue into the pelvic cavity (orthotopic site) or in a heterotopic site once oncological treatment is completed and the patient is disease free. Transplantation of ovarian tissue with sufficiently large numbers of follicles could potentially restore endocrine function and allow multiple cycles for conception. However, the success of ovarian tissue transplantation still has multiple challenges, such as the low number of follicles in the graft that may affect their longevity as well as the survival of the tissue during ex vivo processing and subsequent transplantation. Therefore, this review aims to summarize the achievements of ovary grafting and the potential techniques that have been developed to improve ovarian graft survival.

Pregnancy after Orthotopic Ovarian Tissue Transplantation Using N-hexyl-2-cyanoacrylate

2017 ◽  
Vol 9 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Francisco Fabregues ◽  
Josep Maria Calafell ◽  
Dolors Manau ◽  
Aina Borras ◽  
Joana Peñarrubia ◽  
...  
Keyword(s):  
Ovarian Function ◽  
Ovarian Tissue ◽  
Case Series ◽  
Tissue Transplantation ◽  
Ovarian Activity ◽  
Orthotopic Transplantation ◽  
Adhesion Barrier ◽  
Ovarian Tissue Transplantation ◽  
Estrogen Production ◽  
Case Series Study

Cryopreservation of ovarian tissue in advance of cytotoxic therapies and later transplantation of the tissue is being performed increasingly often, and the total success rates in terms of pregnancy and delivery have been described in case series. Most pregnancies were achieved after orthotopic transplantation of tissue (in the peritoneum or the remaining ovary); however, treatment of the transplantation site during surgery is controversial. In this observational case-series study, we include four patients who underwent ovarian tissue transplantation between 2012 and 2016 by laparoscopy. Previously ovarian tissue was cryopreserved with slow freezing protocol prior to chemo- and/or radiotherapy. After cancer remission, the cryopreserved ovarian tissues were orthotopically re-transplanted in the ovarian medulla by laparoscopy, using N-hexyl-2-cyanoacrylate as an absorbable adhesion barrier. All patients regained ovarian function between 8 and 24 weeks after transplantation, as shown by follicle development and estrogen production. In patients 1 and 2 the ovarian function ended one year after transplantation. Patient 3 has regular menstrual cycles 2 years after the transplant and patient 4 currently has an ongoing spontaneous pregnancy. The use of N-hexyl-2 cyanoacrylate can facilitate the placement of ovarian pieces in orthotopic transplantation by laparoscopy without affecting the restoration and duration of ovarian activity.

Hypothermic Machine Perfusion Versus Cold Storage in the Rescuing of Livers From Non-Heart-Beating Donor Rats

2013 ◽  
Vol 37 (11) ◽  
pp. 985-991 ◽  
Author(s):  
Matías E. Carnevale ◽  
Cecilia L. Balaban ◽  
Edgardo E. Guibert ◽  
Hebe Bottai ◽  
Joaquin V. Rodriguez
Keyword(s):  
Cold Storage ◽  
Machine Perfusion ◽  
Hypothermic Machine Perfusion ◽  
Heart Beating

Time of Cold Storage Prior to Start of Hypothermic Machine Perfusion and Its Influence on Graft Survival

2019 ◽  
Vol 51 (8) ◽  
pp. 2514-2519
Author(s):  
Michal Wszola ◽  
Piotr Domagala ◽  
Agata Ostaszewska ◽  
Lukasz Gorski ◽  
Edyta Karpeta ◽  
...  
Keyword(s):  
Graft Survival ◽  
Cold Storage ◽  
Machine Perfusion ◽  
Hypothermic Machine Perfusion

Ovarian tissue transplantation

2011 ◽  
pp. 357-366 ◽  
Author(s):  
Jacques Donnez ◽  
Jean Squifflet ◽  
Marie-Madeleine Dolmans
Keyword(s):  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Ovarian Tissue Transplantation
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