Study on the separation of ofloxacin enantiomers by hydroxyl-propyl-β-cyclodextrin as a chiral selector in capillary electrophoresis: a computational approach

2015 ◽  
Vol 83 (1-2) ◽  
pp. 119-129 ◽  
Author(s):  
FakhrEldin O. Suliman ◽  
Abdalla A. Elbashir ◽  
Oliver J. Schmitz
Keyword(s):  
Capillary Electrophoresis ◽  
Computational Approach ◽  
Chiral Selector ◽  
Ofloxacin Enantiomers

Determination of enantiomeric excess for 2,3-dihydroxy-3-phenylpropionate compounds by capillary electrophoresis using hydroxypropyl-β-cyclodextrin as chiral selector

Chirality ◽  
2007 ◽  
Vol 19 (5) ◽  
pp. 380-385 ◽  
Author(s):  
Yan Zhao ◽  
Xing-Bin Yang ◽  
Qiao-Feng Wang ◽  
Peng-Juan Nan ◽  
Ying Jin ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Enantiomeric Excess ◽  
Chiral Selector

Evaluation of the macrocyclic antibiotic vancomycin as a chiral selector for capillary electrophoresis

Chirality ◽  
1994 ◽  
Vol 6 (6) ◽  
pp. 496-509 ◽  
Author(s):  
Daniel W. Armstrong ◽  
Kimber L. Rundlett ◽  
Jing-Ran Chen
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Macrocyclic Antibiotic

Fast enantiomeric separation of propranolol by affinity capillary electrophoresis using human serum albumin as chiral selector: application to quality control of pharmaceuticals

2004 ◽  
Vol 507 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Juan José Martı́nez-Pla ◽  
Yolanda Martı́n-Biosca ◽  
Salvador Sagrado ◽  
Rosa Marı́a Villanueva-Camañas ◽  
Marı́a José Medina-Hernández
Keyword(s):  
Quality Control ◽  
Capillary Electrophoresis ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Enantiomeric Separation ◽  
Chiral Selector ◽  
Affinity Capillary Electrophoresis

Determination of Ofloxacin Enantiomers in Pharmaceutical Formulations by Capillary Electrophoresis

2007 ◽  
Vol 31 (3) ◽  
pp. 348-360 ◽  
Author(s):  
Abdalla A. Elbashir ◽  
Bahruddin Saad ◽  
Abdussalam Salhin Mohamed Ali ◽  
Muhammad Idiris Saleh ◽  
Hassan Y. Aboul‐Enein
Keyword(s):  
Capillary Electrophoresis ◽  
Pharmaceutical Formulations ◽  
Ofloxacin Enantiomers

scholarly journals Development of a Capillary Electrophoresis Method for the Enantioselective Estimation of Primaquine in Pharmaceutical Formulations

2008 ◽  
Vol 91 (3) ◽  
pp. 536-541 ◽  
Author(s):  
Abdalla A Elbashir ◽  
Bahruddin Saad ◽  
Abdussalam Salhin Mohamed Ali ◽  
Muhammad Idiris Saleh
Keyword(s):  
Capillary Electrophoresis ◽  
Applied Voltage ◽  
Pharmaceutical Formulations ◽  
Fused Silica ◽  
Chiral Selector ◽  
Effective Length ◽  
Racemic Mixture ◽  
Injection Time ◽  
Relative Standard ◽  
Capillary Temperature

Abstract A capillary electrophoresis (CE) method has been developed that allows the separation and estimation of primaquine enantiomers using hydroxypropyl--cyclodextrin (HP--CD) as a chiral selector. The influence of chemical and instrumental parameters on the separation, such as type and concentration of CD, buffer concentration, buffer pH, applied voltage, capillary temperature, and injection time, were investigated. Good separation of the racemic mixture of primaquine was achieved using a fused-silica capillary (52.5 cm effective length 50 m id) and a background electrolyte composed of tris-phosphate buffer solution (50 mM, pH 2.5) containing 15 mM HP--CD as a chiral selector. The recommended applied voltage, capillary temperature, and injection time were 15 kV, 25C, and 6 s, respectively. Within-day and interday reproducibility of peak area and migration time gave relative standard deviation values ranging from 1.053.30. Good recoveries (range of 96.8104.9) were obtained from the determination of placebos that were spiked with 0.251.00 mg/L primaquine. The proposed CE method was successfully applied to the assay of primaquine diphosphate in pharmaceutical formulations (tablets).

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