Erlotinib/hydroxypropyl-β-cyclodextrin inclusion complex: characterization and in vitro and in vivo evaluation

2015 ◽  
Vol 83 (3-4) ◽  
pp. 267-279 ◽  
Author(s):  
Sávio M. L. Gontijo ◽  
Pedro P. G. Guimarães ◽  
Celso T. R. Viana ◽  
Ângelo M. L. Denadai ◽  
Alinne D. M. Gomes ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vivo Evaluation ◽  
Cyclodextrin Inclusion ◽  
Complex Characterization ◽  
Cyclodextrin Inclusion Complex

scholarly journals In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fahima M. Hashem ◽  
Mohamed Mostafa ◽  
Mahmoud Shaker ◽  
Mohamed Nasr
Keyword(s):  
Inclusion Complex ◽  
Drug Product ◽  
Water Soluble ◽  
In Vivo Evaluation ◽  
Water Soluble Polymers ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Dissolution Efficiency

The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide with β-cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.

In vitro and in vivo evaluation of a posaconazole-sulfobutyl ether-β -cyclodextrin inclusion complex

2018 ◽  
Vol 32 (12) ◽  
pp. e4364 ◽  
Author(s):  
Miao Wang ◽  
Juan Jiang ◽  
Yi Cai ◽  
Min Zhao ◽  
Qijuan Wu ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vivo Evaluation ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Sulfobutyl Ether

Preparation of celecoxib-dimethyl-β-cyclodextrin inclusion complex: characterization and in vitro permeation study

2005 ◽  
Vol 40 (7) ◽  
pp. 624-631 ◽  
Author(s):  
Cinzia Anna Ventura ◽  
Ignazio Giannone ◽  
Donatella Paolino ◽  
Venerando Pistarà ◽  
Antonino Corsaro ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Permeation Study ◽  
In Vitro Permeation ◽  
Complex Characterization ◽  
Cyclodextrin Inclusion Complex

Development of an oral satraplatin pharmaceutical formulation by encapsulation with cyclodextrin

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17074-17082 ◽  
Author(s):  
Jian-Qiang Zhang ◽  
Ke Li ◽  
Kun-Ming Jiang ◽  
Yan-Wei Cong ◽  
Shao-Ping Pu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Inclusion Complex ◽  
In Vitro Cytotoxicity ◽  
Pharmaceutical Formulation ◽  
Water Soluble ◽  
Cytotoxicity Test ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

A novel water-soluble oral satraplatin/β-cyclodextrin inclusion complex was prepared and characterized with a variety of techniques. The inclusion complex showed much higher antitumor activity in vitro cytotoxicity test and in vivo antitumor test.

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