The Necessary Conditions of Fractional Optimal Control in the Sense of Caputo

2012 ◽  
Vol 156 (1) ◽  
pp. 115-126 ◽  
Author(s):  
Tian Liang Guo
2020 ◽  
Vol 23 (6) ◽  
pp. 1783-1796
Author(s):  
Neelam Singha

Abstract In this article, we aim to analyze a mathematical model of tumor growth as a problem of fractional optimal control. The considered fractional-order model describes the interaction of effector-immune cells and tumor cells, including combined chemo-immunotherapy. We deduce the necessary optimality conditions together with implementing the Adomian decomposition method on the suggested fractional-order optimal control problem. The key motive is to perform numerical simulations that shall facilitate us in understanding the behavior of state and control variables. Further, the graphical interpretation of solutions effectively validates the applicability of the present analysis to investigate the growth of cancer cells in the presence of medical treatment.


2018 ◽  
Vol 180 (2) ◽  
pp. 556-573 ◽  
Author(s):  
Wen Li ◽  
Song Wang ◽  
Volker Rehbock

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