scholarly journals Type 1 diabetes mellitus induces structural changes and molecular remodelling in the rat kidney

2018 ◽  
Vol 449 (1-2) ◽  
pp. 9-25 ◽  
Author(s):  
Raphael M. Singh ◽  
Frank C. Howarth ◽  
Ernest Adeghate ◽  
Keshore Bidasee ◽  
Jaipaul Singh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Rat Kidney

Structural changes in erythrocyte membranes under type 1 diabetes mellitus

2008 ◽  
Vol 21 (2) ◽  
pp. 211-214
Author(s):  
Nataliya Sybirna ◽  
Tetyana Buslyk ◽  
Nataliya Klymyshyn ◽  
Andriy Hnatush ◽  
Maria Duk ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Erythrocyte Membranes

scholarly journals How the sialylation level of serum N-acetyl-β-D-glucosaminidase a form in type 1 diabetes mellitus influences its activity?

2014 ◽  
Vol 79 (12) ◽  
pp. 1491-1503
Author(s):  
Vesna Jovanovic ◽  
Jelena Acimovic ◽  
Vesna Dimitrijevic-Sreckovic ◽  
Ljuba Mandic
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Negative Charge ◽  
Total Serum ◽  
Secondary Complications ◽  
Isoenzyme Patterns ◽  
Healthy Persons

It has been verified that serum N-acetyl-?-D-glucosaminidase (NAG) activity is elevated in diabetes, but there are no reports about changes of the sialic acid (SA) content in the carbohydrate parts of NAG A form and its influence on total NAG activity changes in type 1 diabetes mellitus patients without and with secondary complications. NAG A forms were isolated, purified and characterized from the serum of 81 IDDM patients with and without secondary complications (retinopathy, polyneuropathy and nephropathy) and 25 healthy persons. The content of ?-2,6-bound SA and isoenzyme patterns of purified A form, total NAG and A form activities were determined. In all diabetic groups, A form sialylation levels were 2-3.5 times lower compared to control, while their acidities (fractions with pI 4.25-5.1) increased, particularly with progression of secondary complications. Total serum NAG activities and percentages of A form were significantly higher (P<0.001) in all diabetic groups and negatively correlated with the ?-2,6-bound SA content of the A form. In addition, they decreased as secondary diabetic complications became more complex. Observed changes could be the consequence of structural changes in the A form due to significant increase in its acidity, i.e. negative charge which originate from groups other than SA.

The branching pattern of villous capillaries and structural changes of placental terminal villi in type 1 diabetes mellitus

Placenta ◽  
2012 ◽  
Vol 33 (5) ◽  
pp. 343-351 ◽  
Author(s):  
M. Jirkovská ◽  
T. Kučera ◽  
J. Kaláb ◽  
M. Jadrníček ◽  
V. Niedobová ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Branching Pattern ◽  
Terminal Villi

Structural changes of bone tissue in patients with type 1 diabetes mellitus

2019 ◽  
Author(s):  
Volha Vadzianava ◽  
Yuliya Dydyshka ◽  
Nadzeya Karytska ◽  
Alla Shepelkevich ◽  
Natalya Vasilyeva
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Bone Tissue ◽  
Structural Changes
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