Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: a molecular insight

2018 ◽  
Vol 46 (1) ◽  
pp. 957-963 ◽  
Author(s):  
Baishali Alok Jana ◽  
Pavan Kumar Chintamaneni ◽  
Praveen Thaggikuppe Krishnamurthy ◽  
Ashish Wadhwani ◽  
Suresh Kumar Mohankumar
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
High Fat Diet ◽  
High Fat ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

scholarly journals Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by a paternal high‐fat diet

2018 ◽  
Vol 597 (1) ◽  
pp. 121-136 ◽  
Author(s):  
Filippe Falcão‐Tebas ◽  
Jujiao Kuang ◽  
Chelsea Arceri ◽  
Jarrod P. Kerris ◽  
Sofianos Andrikopoulos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
High Fat Diet ◽  
High Fat ◽  
Adult Skeletal Muscle ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

scholarly journals Nox2 Mediates Skeletal Muscle Insulin Resistance Induced by a High Fat Diet

2015 ◽  
Vol 290 (21) ◽  
pp. 13427-13439 ◽  
Author(s):  
Alvaro Souto Padron de Figueiredo ◽  
Adam B. Salmon ◽  
Francesca Bruno ◽  
Fabio Jimenez ◽  
Herman G. Martinez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
High Fat Diet ◽  
High Fat ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

Skeletal Muscle Insulin Resistance in Rats Fed a High Fat Diet and Treated with Acipimox

2006 ◽  
Vol 38 (Suppl 1) ◽  
pp. S44
Author(s):  
Chad R. Hancock ◽  
David C. Wright ◽  
Dong Ho Han ◽  
John O. Holloszy
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
High Fat Diet ◽  
High Fat ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats

2001 ◽  
Vol 281 (1) ◽  
pp. E62-E71 ◽  
Author(s):  
Charles Lavigne ◽  
Frédéric Tremblay ◽  
Geneviève Asselin ◽  
Hélène Jacques ◽  
André Marette
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Amino Acids ◽  
Glucose Uptake ◽  
Soy Protein ◽  
Whole Body ◽  
Glucose Disposal ◽  
High Fat ◽  
Muscle Insulin Resistance ◽  
Skeletal Muscle Insulin Resistance

In the present study, we tested the hypothesis that fish protein may represent a key constituent of fish with glucoregulatory activity. Three groups of rats were fed a high-fat diet in which the protein source was casein, fish (cod) protein, or soy protein; these groups were compared with a group of chow-fed controls. High-fat feeding led to severe whole body and skeletal muscle insulin resistance in casein- or soy protein-fed rats, as assessed by the euglycemic clamp technique coupled with measurements of 2-deoxy-d-[3H]glucose uptake rates by individual tissues. However, feeding cod protein fully prevented the development of insulin resistance in high fat-fed rats. These animals exhibited higher rates of insulin-mediated muscle glucose disposal that were comparable to those of chow-fed rats. The beneficial effects of cod protein occurred without any reductions in body weight gain, adipose tissue accretion, or expression of tumor necrosis factor-α in fat and muscle. Moreover, L6 myocytes exposed to cod protein-derived amino acids showed greater rates of insulin-stimulated glucose uptake compared with cells incubated with casein- or soy protein-derived amino acids. These data demonstrate that feeding cod protein prevents obesity-induced muscle insulin resistance in high fat-fed obese rats at least in part through a direct action of amino acids on insulin-stimulated glucose uptake in skeletal muscle cells.

132 Mitochondrial dysfunction preceeds insulin resistance in skeletal muscle of mice fed high fat diet

Mitochondrion ◽  
2010 ◽  
Vol 10 (2) ◽  
pp. 237 ◽  
Author(s):  
Sihem Boudina ◽  
Sandra Sena ◽  
Robert C. Cooksey ◽  
Deborah Jones ◽  
Donald A. McClain ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
High Fat Diet ◽  
High Fat
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