Effects of Probiotic Enterococci and Glatiramer Acetate on the Severity of Experimental Allergic Encephalomyelitis in Rats

2017 ◽  
Vol 47 (7) ◽  
pp. 866-876 ◽  
Author(s):  
I. N. Abdurasulova ◽  
E. I. Ermolenko ◽  
A. V. Matsulevich ◽  
K. O. Abdurasulova ◽  
E. A. Tarasova ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Experimental Allergic Encephalomyelitis ◽  
Allergic Encephalomyelitis ◽  
Experimental Allergic

scholarly journals Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate

2011 ◽  
Vol 232 (1-2) ◽  
pp. 136-144 ◽  
Author(s):  
Sakhina Begum-Haque ◽  
Marc Christy ◽  
Javier Ochoa-Reparaz ◽  
Elizabeth C. Nowak ◽  
Daniel Mielcarz ◽  
...  
Keyword(s):  
B Cell ◽  
Glatiramer Acetate ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Activity ◽  
Allergic Encephalomyelitis ◽  
Regulatory B Cell ◽  
Experimental Allergic

Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells

2016 ◽  
Vol 7 (5) ◽  
pp. 719-729 ◽  
Author(s):  
I.N. Abdurasulova ◽  
A.V. Matsulevich ◽  
E.A. Tarasova ◽  
I.V. Kudryavtsev ◽  
M.K. Serebrjakova ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Experimental Allergic Encephalomyelitis ◽  
Immune Cells ◽  
Enterococcus Faecium ◽  
Protective Action ◽  
Allergic Encephalomyelitis ◽  
Mild Disease ◽  
Control Drug ◽  
Experimental Allergic ◽  
Faecium Strain

The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.

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