scholarly journals Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium

2019 ◽  
Vol 143 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Rafael Ceschin ◽  
Mehmet Kocak ◽  
Sridhar Vajapeyam ◽  
Ian F. Pollack ◽  
Arzu Onar-Thomas ◽  
...  
2015 ◽  
Vol 22 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Robert V. Mulkern ◽  
Kelsey I. Ricci ◽  
Sridhar Vajapeyam ◽  
Thomas L. Chenevert ◽  
Dariya I. Malyarenko ◽  
...  

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i100-i100 ◽  
Author(s):  
Eugene Hwang ◽  
Arzu Onar ◽  
Tina Young-Poussaint ◽  
Duane Mitchell ◽  
Lindsay Kilburn ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dilakshan Srikanthan ◽  
Michael S. Taccone ◽  
Randy Van Ommeren ◽  
Joji Ishida ◽  
Stacey L. Krumholtz ◽  
...  

AbstractDiffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor and the leading cause of brain tumor–related death in children. As several clinical trials over the past few decades have led to no significant improvements in outcome, the current standard of care remains fractionated focal radiation. Due to the recent increase in stereotactic biopsies, tumor tissue availabilities have enabled our advancement of the genomic and molecular characterization of this lethal cancer. Several groups have identified key histone gene mutations, genetic drivers, and methylation changes in DIPG, providing us with new insights into DIPG tumorigenesis. Subsequently, there has been increased development of in vitro and in vivo models of DIPG which have the capacity to unveil novel therapies and strategies for drug delivery. This review outlines the clinical characteristics, genetic landscape, models, and current treatments and hopes to shed light on novel therapeutic avenues and challenges that remain.


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