Compatibility studies between piroxicam and pharmaceutical excipients used in solid dosage forms

2008 ◽  
Vol 42 (4) ◽  
pp. 215-219 ◽  
Author(s):  
H. K. Stulzer ◽  
M. P. Tagliari ◽  
A. P. Cruz ◽  
M. A. S. Silva ◽  
M. C. M. Laranjeira
Keyword(s):  
Dosage Forms ◽  
Compatibility Studies ◽  
Solid Dosage Forms ◽  
Pharmaceutical Excipients ◽  
Solid Dosage

scholarly journals Compatibility Studies of Valsartan with Different Pharmaceutical Excipients

2019 ◽  
Vol 70 (7) ◽  
pp. 2590-2600
Author(s):  
Ioana Cristina Tita ◽  
Lavinia Lupa ◽  
Bogdan Tita ◽  
Roxana Liana Stan ◽  
Laura Vicas
Keyword(s):  
Magnesium Stearate ◽  
Dosage Forms ◽  
Compatibility Studies ◽  
Scanning Calorimetry ◽  
Pharmaceutical Dosage Forms ◽  
Lactose Monohydrate ◽  
Pharmaceutical Excipients ◽  
Solid Dosage ◽  
Fourier Transformed Infrared Spectroscopy ◽  
Ft Ir

Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimetry (DSC) were used for a first screening to find small variations in peak temperature and/or their associated enthalpy for six drug/excipient mixtures (starch, cross caramelose sodique, microcrystalline cellulose 102, povidone K30, lactose monohydrate and magnesium stearate), which indicate some degree of interaction. Additional methods using Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) confirmed the incompatibility of VALS with starch, povidone K30, lactose monohydrate and magnesium stearate. Those excipients should be avoided in the development of solid dosage forms.

ChemInform Abstract: New Pharmaceutical Excipients in Solid Dosage Forms

ChemInform ◽  
2012 ◽  
Vol 43 (32) ◽  
pp. no-no
Author(s):  
Hardik Patel ◽  
Viral Shah ◽  
Umesh Upadhyay
Keyword(s):  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Pharmaceutical Excipients ◽  
Solid Dosage

Compatibility study between chitosan and pharmaceutical excipients used in solid dosage forms

2014 ◽  
Vol 116 (2) ◽  
pp. 1091-1100 ◽  
Author(s):  
M. A. V. Pereira ◽  
G. D. Fonseca ◽  
A. A. Silva-Júnior ◽  
M. F. Fernandes-Pedrosa ◽  
M. de F. V. de Moura ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Compatibility Study ◽  
Solid Dosage Forms ◽  
Pharmaceutical Excipients ◽  
Solid Dosage

Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms

2011 ◽  
Vol 56 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Bogdan Tiţa ◽  
Adriana Fuliaş ◽  
Geza Bandur ◽  
Eleonora Marian ◽  
Dumitru Tiţa
Keyword(s):  
Dosage Forms ◽  
Compatibility Study ◽  
Solid Dosage Forms ◽  
Pharmaceutical Excipients ◽  
Solid Dosage

Compatibility study between sitagliptin and pharmaceutical excipients used in solid dosage forms

2013 ◽  
Vol 115 (3) ◽  
pp. 2423-2428 ◽  
Author(s):  
S. Shantikumar ◽  
G. Sreekanth ◽  
K. V. SurendraNath ◽  
S. JaferValli ◽  
N. Satheeshkumar
Keyword(s):  
Dosage Forms ◽  
Compatibility Study ◽  
Solid Dosage Forms ◽  
Pharmaceutical Excipients ◽  
Solid Dosage
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