pharmaceutical dosage forms
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2022 ◽  
Aseel M. Aljeboree ◽  
Layth S. Jasim ◽  
Firas H. Abdulrazzak ◽  
Ibrahim J. Sahib ◽  
Nadher D. Radia ◽  

Naresh Kshirasagar ◽  
Goverdhan Puchchakayala ◽  
Balamurugan. K

Oral administration of the non-steroidal anti-inflammatory drug, Diclofenac Diethylamine (DDEA) is often associated with gastrointestinal ulcers, bleeding and extensive first-pass hepatic metabolism. As an alternative to oral administration, formulated microsponges-based gel of DDEA was developed for topical administration, to quantify diclofenac diethylamine in plasma of rabbits for this a sensitive Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method was developed using carbamazepine as Internal standard (IS) and DDEA (pure drug) was provoked on Hypersil RP C18 column (250mm × 4.6mm 5µm) using a mobile phase mixture of potassium dihydrogen buffer pH 2.5 and acetonitrile in the ratio of 30:70 v/v at an isocratic flow rate of 1mL/min. The drug peak area was detection and found at 276nm. The retention time of DDEA was found to be 5.3 min. The calibration curve was linear over the concentration range of 50-750ng/ml of DDEA. This method was accurate for quantitative estimation of the drug from the marketed gel and optimized microsponge gel. The main of investigation is to compare pharmacokinetic profile of diclofenac diethylamine in pharmaceutical dosage forms (marketed gel and microsponges gel) using WinNonlin software version 8.1.

Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 92
Khaled M. Hosny ◽  
Hala M. Alkhalidi ◽  
Waleed S. Alharbi ◽  
Shadab Md ◽  
Amal M. Sindi ◽  

Natural polymers are revolutionizing current pharmaceutical dosage forms design as excipient and gained huge importance because of significant influence in formulation development and drug delivery. Oral health refers to the health of the teeth, gums, and the entire oral-facial system that allows us to smile, speak, and chew. Since years, biopolymers stand out due to their biocompatibility, biodegradability, low toxicity, and stability. Polysaccharides such as cellulose and their derivatives possess properties like novel mechanical robustness and hydrophilicity that can be easily fabricated into controlled-release dosage forms. Cellulose attracts the dosage design attention because of constant drug release rate from the precursor nanoparticles. This review discusses the origin, extraction, preparation of cellulose derivatives and their use in formulation development of nanoparticles having multidisciplinary applications as pharmaceutical excipient and in drug delivery, as bacterial and plant cellulose have great potential for application in the biomedical area, including dentistry, protein and peptide delivery, colorectal cancer treatment, and in 3D printable dosage forms.

Abhishek Chandola ◽  
Meenakshi Bhatt

The present work is done to develop a new simple, rapid, specific, accurate and precise UV spectrophotometric method for Montelukast as API and in pharmaceutical dosage form. The validation of the proposed method was carried out according to the I.C.H guidelines. The wavelength maxima was found 270nm and calibration curves were obtained in the concentration range 5-45?g/ml for montelukast with good correlation coefficients (r2=0.9994.). The precisions of the new method for montelukast was less than the maximum allowable limit (%RSD <2.0) specified by the ICH. Therefore, the method was found to be an accurate, reproducible and sensitive for analysis of montelukast as standard, pharmaceutical dosage forms, and other routine analysis method.

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2184
Enas Alaa El-din Abd El-aziz ◽  
Sherif Farouk Elgayar ◽  
Fatma M. Mady ◽  
Mohammed A. S. Abourehab ◽  
Omiya Ali Hasan ◽  

Purpose: Development of pharmaceutical dosage forms of natural products has gained great interest recently. Propolis is a natural product with various active compounds and multiple pharmacological activities. Its resinous nature and low bioavailability were obstacles in the optimum use of this magnificent natural product. Aim: This study evaluates the effect of using liposomes as a drug delivery system on the enhancement of the cytotoxic effect of propolis on squamous cell carcinoma cell lines (Hep-2) of head and neck. Methods: An optimized liposomal formulation of propolis was prepared using the conventional thin film hydration method 1, 2. The prepared (Hep-2) cell line was treated with different concentrations of propolis and optimized propolis liposomes for 24 h. The effect of both propolis and propolis liposomes on cell line was investigated using MTT assay, cytological examination, and nuclear morphometric analysis. The effect of the drugs on the cell apoptosis was evaluated using Annexin V. Results: The findings revealed that both propolis and propolis liposomes have a cytotoxic effect on Hep-2 cell line through induction of apoptosis. The effect was dose dependent. However, a statistically significant enhancement in propolis-mediated apoptosis on Hep-2 cells was elucidated due to encapsulation within the prepared liposomes. Conclusion: Liposome is a powerful tool for enhancing the cytotoxicity of propolis against Hep-2 cell line.

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