Development of a Level A in Vitro-in Vivo Correlation for Veliparib (ABT-888) Extended Release Tablet Formulation

2017 ◽  
Vol 34 (6) ◽  
pp. 1187-1192 ◽  
Author(s):  
Rajendar K. Mittapalli ◽  
Silpa Nuthalapati ◽  
Alyssa E. Delke DeBord ◽  
Hao Xiong
Keyword(s):  
Extended Release ◽  
Tablet Formulation ◽  
Extended Release Tablet ◽  
Release Tablet

Development of In Vitro-In Vivo Correlation for Potassium Chloride Extended Release Tablet Formulation Using Urinary Pharmacokinetic Data

2017 ◽  
Vol 34 (7) ◽  
pp. 1527-1533 ◽  
Author(s):  
Rajendar K. Mittapalli ◽  
Patrick Marroum ◽  
Yihong Qiu ◽  
Kathleen Apfelbaum ◽  
Hao Xiong
Keyword(s):  
Potassium Chloride ◽  
Extended Release ◽  
Tablet Formulation ◽  
Pharmacokinetic Data ◽  
Extended Release Tablet ◽  
Release Tablet

Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation

2004 ◽  
Vol 58 (3) ◽  
pp. 607-614 ◽  
Author(s):  
Yaw-Bin Huang ◽  
Yi-Hung Tsai ◽  
Wan-Chiech Yang ◽  
Jui-Sheng Chang ◽  
Pao-Chu Wu ◽  
...  
Keyword(s):  
Dosage Form ◽  
Extended Release ◽  
Formulation Design ◽  
Once Daily ◽  
Tablet Dosage ◽  
Extended Release Tablet ◽  
Release Tablet

Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations

2010 ◽  
Vol 383 (1-2) ◽  
pp. 99-105 ◽  
Author(s):  
Shinichiro Tajiri ◽  
Taro Kanamaru ◽  
Kamada Makoto ◽  
Tsutomu Konno ◽  
Hiroaki Nakagami
Keyword(s):  
Dosage Form ◽  
Extended Release ◽  
In Vivo Evaluation ◽  
Dosage Form Design ◽  
Form Design ◽  
Tablet Formulations ◽  
Extended Release Tablet ◽  
Release Tablet

PALATABILITY ASSESSMENT OF A NEW AMPHETAMINE EXTENDED-RELEASE TABLET FORMULATION

2020 ◽  
Vol 59 (10) ◽  
pp. S264
Author(s):  
Antonio Pardo ◽  
Thomas R. King ◽  
Eman Rafla ◽  
Judith C. Kando ◽  
Amy Everitt
Keyword(s):  
Extended Release ◽  
Tablet Formulation ◽  
Extended Release Tablet ◽  
Release Tablet

Pharmacokinetics of a Novel Diltiazem HCl Extended-Release Tablet Formulation for Evening Administration

2003 ◽  
Vol 43 (10) ◽  
pp. 1149-1157 ◽  
Author(s):  
Suryanarayana Sista ◽  
John Chi-Keung Lai ◽  
Okponanabofa Eradiri ◽  
Kenneth S. Albert
Keyword(s):  
Extended Release ◽  
Tablet Formulation ◽  
Diltiazem Hcl ◽  
Evening Administration ◽  
Extended Release Tablet ◽  
Release Tablet

scholarly journals Formulation, Development, and Optimization of Anti- Hypertensive Nisoldipine Extended-Release Tablet Formulation

2020 ◽  
Vol 5 (03) ◽  
pp. 37-44
Author(s):  
Kukkadapu Pavan Kumar ◽  
Katta Sunand ◽  
Nerella Mounika ◽  
Mohammed Abdul Samad ◽  
A. Madhu Babu ◽  
...  
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Aqueous Solubility ◽  
Cellular Membrane ◽  
Tablet Formulation ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Release Tablet

A drug molecule has to be water-soluble to be readily delivered to the cellular membrane. Many drugs are waterinsoluble, which creates numerous problems in the development of dosage forms. Controlled drug delivery formulation releases the drug with controlled kinetics for days and months, reducing the frequency of dosing, minimizing side effects, and improving patient compliance. Nisoldipine is a calcium channel antagonist that is indicated for the treatment of hypertension with very poor aqueous solubility. Thus, there is a need to improve the rate of drug release. Hence, the study was carried out to design, formulate and evaluate sustained-release tablet formulation of nisoldipine. Nisoldipine controlled release matrix tablets were prepared by roll compaction method. Preformulation studies have confirmed the purity and compatibility of drug with excipients used in the formulation. Pre-compression studies have confirmed the stability of formulation blends for compression. All the prepared formulations were evaluated for various physical and compression parameters such as bulk and tapped density, hardness, friability, and in vitro drug release studies. The results of drug release from prepared compressed nisoldipine extended-release tablets were found to be within the desired range.

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