Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem.

Microencapsulation of formulation designs further expands the field and offers the potential for use in developing bioartificial organs via cell encapsulation. Combining formulation design and encapsulation requires ideal excipients to be determined. In terms of cell encapsulation, an environment which allows growth and functionality is paramount to ensuring cell survival and incorporation into a bioartificial organ. Hence, excipients are examined for both individual properties and benefits, and compatibility with encapsulated active materials. Polymers are commonly used in microencapsulation, offering protection from the immune system. Bile acids are emerging as a tool to enhance delivery, both biologically and pharmaceutically. Therefore, this review will focus on bile acids and polymers in formulation design via microencapsulation, in the field of bioartificial organ development.

An All-Inclusive Laboratory Workflow for the Development of Surfactant/Polymer Formulations for EOR in Harsh Carbonates

Carbonate reservoirs are challenging for chemical EOR, particularly in selecting fine-tuned chemical formulations which combine high performance, stable behavior, and trouble-free operations. The design of suitable formulations requires substantial laboratory work and a solid methodology. In this paper, a systematic all-inclusive laboratory workflow to design a surfactant-polymer (SP) formulation for a carbonate reservoir is presented. In this work, a complete process for development and evaluation of an SP formulation for high-salinity high-temperature conditions is proposed and adopted. For which, a high throughput robotic platform is used for efficient and robust formulation design. The process is illustrated on an actual case with harsh reservoir conditions (i.e. a high temperature of 100℃ and high connate salinity of 213,000 mg/L). The SP design methodology consisted of five steps: surfactant design, polymer selection, surfactant/polymer verification, topside assessment, and oil-displacement evaluation. The surfactant formulation design consisted of four substeps: solubility scans, phase-behavior scans (salinity scans), IFT measurements, and static adsorption tests. The sourced polymers were screened based on three key performance indicators: viscosity, filter ratio, and thermal stability. The selected surfactant formulations and polymers were then assessed as sloppy slugs in terms of compatibility and injectivity. Then, the unique topside assessment was conducted where it consisted of two components focusing on: separation kinetics and separated water quality. Finally, an oil displacement study was performed using a preserved composite plug, in which the SP formulation developed through the outlined process was used. The results demonstrate the potential of a mixture of Olefin Sulfonate (OS) and Alkyl Glyceryl Ether Sulfonate (AGES). The results also illustrate couple of polymers with stabilities suitable for high temperature conditions: an associative polymer, and an AM/AMPS copolymer. In addition, injectivity corefloods supported the SP slug transportability across the porous media. Corefloods also demonstrated the SP slug capacity to recover around 62% ROIC (remaining oil in core). Finally, SP in produced brines improved the separation kinetics but lead to a slight deterioration in separated water quality. A key novelty of the adopted workflow is the integration of topside assessment. In addition, the experimental steps were clearly delineated including the preparation of representative oils. Beside a clear layout of the methodology, the work demonstrates that a surfactant-polymer formulation can successfully be designed for high temperature carbonate reservoirs and provide encouraging guidelines with respect to SP impact on topside facilities.