In this paper, we explore the dynamics and protection of quantum coherence in an open system under non-inertial frames by weak measurement and reversal, and design four strategies to protect the quantum coherence of an initial two-qubit entangled state, when the systems suffer from amplitude damping (AD) channel and one subsystem is under non-inertial frames. In practice, there is no strict inertial frames, decoherence and degradation of the quantum coherence caused by the Unruh effect form acceleration will have a significant interaction, therefore it is important to find some means to protect quantum coherence under non-inertial frames.