scholarly journals Comparison of the [18F]-FDG and [18F]-FLT PET Tracers in the Evaluation of the Preclinical Proton Therapy Response in Hepatocellular Carcinoma

Author(s):  
David Brasse ◽  
Hélène Burckel ◽  
Patrice Marchand ◽  
Marc Rousseau ◽  
Ali Ouadi ◽  
...  
Author(s):  
Keisuke Miyake ◽  
Kenta Suzuki ◽  
Tomoya B Ogawa ◽  
Daisuke Ogawa ◽  
Tetsuhiro Hatakeyama ◽  
...  

Abstract Background The molecular diagnosis of gliomas such as isocitrate dehydrogenase (IDH) status (wild-type [wt] or mutation [mut]) is especially important in the 2016 WHO classification. Positron emission tomography (PET) has afforded molecular and metabolic diagnostic imaging. The present study aimed to define the interrelationship between the 2016 WHO classification of gliomas and the integrated data from PET images using multiple tracers, including 18F-fluorodeoxyglucose ( 18F-FDG), 11C-methionine ( 11C-MET), 18F-fluorothymidine ( 18F-FLT), and 18F-fluoromisonidazole ( 18F-FMISO). Methods This retrospective, single-center study comprised 113 patients with newly diagnosed glioma based on the 2016 WHO criteria. Patients were divided into four glioma subtypes (Mut, Codel, Wt, and glioblastoma multiforme [GBM]). Tumor standardized uptake value (SUV) divided by mean normal cortical SUV (tumor-normal tissue ratio [TNR]) was calculated for 18F-FDG, 11C-MET, and 18F-FLT. Tumor-blood SUV ratio (TBR) was calculated for 18F-FMISO. To assess the diagnostic accuracy of PET tracers in distinguishing glioma subtypes, a comparative analysis of TNRs and TBR as well as the metabolic tumor volume (MTV) were calculated by Scheffe’s multiple comparison procedure for each PET tracer following the Kruskal–Wallis test. Results The differences in mean 18F-FLT TNR and 18F-FMISO TBR were significant between GBM and other glioma subtypes (p < 0.001). Regarding the comparison between Gd-T1WI volumes and 18F-FLT MTVs or 18F-FMISO MTVs, we identified significant differences between Wt and Mut or Codel (p < 0.01). Conclusion Combined administration of four PET tracers might aid in the preoperative differential diagnosis of gliomas according to the 2016 WHO criteria.


2016 ◽  
Vol 27 (suppl_9) ◽  
Author(s):  
S.H. Lee ◽  
K.C. Lee ◽  
K. Sung ◽  
E.Y. Choi ◽  
J.B. Bae ◽  
...  

2018 ◽  
Vol 43 (12) ◽  
pp. e482-e483
Author(s):  
Raja Senthil ◽  
H Ramesh ◽  
Arun Visakh R. ◽  
Thara Pratap ◽  
Pushpa Mahadevan

2015 ◽  
Vol 36 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Hyo Jung Seo ◽  
Gun Min Kim ◽  
Joo Hoon Kim ◽  
Won Jun Kang ◽  
Hye Jin Choi

2010 ◽  
Vol 51 (12) ◽  
pp. 1870-1877 ◽  
Author(s):  
V. Frings ◽  
A. J. de Langen ◽  
E. F. Smit ◽  
F. H. P. van Velden ◽  
O. S. Hoekstra ◽  
...  

2016 ◽  
Vol 57 (12) ◽  
pp. 1851-1857 ◽  
Author(s):  
C. B. Johnbeck ◽  
U. Knigge ◽  
S. W. Langer ◽  
A. Loft ◽  
A. K. Berthelsen ◽  
...  

2006 ◽  
Vol 4 (2) ◽  
pp. 159
Author(s):  
I. Segaert ◽  
Neven ◽  
S. Stroobants ◽  
M. Drijkoningen ◽  
F. Amant ◽  
...  

2015 ◽  
Vol 40 (6) ◽  
pp. e325-e327 ◽  
Author(s):  
Do-Hoon Kim ◽  
Shin Young Jeong ◽  
Sang-Woo Lee ◽  
Jaetae Lee ◽  
Byeong-Cheol Ahn

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