Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis

Huan He ◽  
Wenjing Chen ◽  
Yu Wei ◽  
Taifa Zhang ◽  
Wenfeng Geng ◽  
2017 ◽  
Vol 33 (7) ◽  
pp. 601-609 ◽  
Iwona Sidorkiewicz ◽  
Kamil Zaręba ◽  
Sławomir Wołczyński ◽  
Jan Czerniecki

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that can cause disturbances in the endocrine system and have multiple harmful effects on health by targeting different organs and systems in the human body. Mass industrial production and widespread use of EDCs have resulted in worldwide contamination. Accumulating evidence suggest that human exposure to EDCs is related to the impairment of male reproductive function and can interrupt other hormonally regulated metabolic processes, particularly if exposure occurs during early development. Investigation of studies absent in previous reviews and meta-analysis of adverse effects of EDCs on functioning of the male reproductive system is the core of this work. Four main modes of action of EDCs on male fertility have been summarized in this review. First, studies describing estrogen- pathway disturbing chemicals are investigated. Second, androgen-signaling pathway alterations and influence on androgen sensitive tissues are examined. Third, evaluation of steroidogenesis dysfunction is discussed by focusing on the steroid hormone biosynthesis pathway, which is targeted by EDCs. Last, the reportedly destructive role of reactive oxygen species (ROS) on sperm function is discussed. Spermatogenesis is a remarkably complex process, hence multiple studies point out various dysfunctions depending on the development state at which the exposure occurred. Collected data show the need to account for critical windows of exposure such as fetal, perinatal and pubertal periods as well as effects of mixtures of several compounds in future research.

2016 ◽  
Vol 61 ◽  
pp. 186-194 ◽  
Hanna Katarina Lilith Johansson ◽  
Pernille Rosenskjold Jacobsen ◽  
Ulla Hass ◽  
Terje Svingen ◽  
Anne Marie Vinggaard ◽  

2016 ◽  
Vol 124 (11) ◽  
pp. 1785-1793 ◽  
Laura Birks ◽  
Maribel Casas ◽  
Ana M. Garcia ◽  
Jan Alexander ◽  
Henrique Barros ◽  

2001 ◽  
Vol 9 (2) ◽  
pp. 61-80 ◽  
D Crump

Statistical meta-analysis of large and diverse data sets has indicated that amphibians have been declining worldwide since the 1960s. Exposure to UV-B radiation (280–320 nm) and endocrine-disrupting chemicals (EDCs) have been considered as possible hypotheses to explain the observed declines. Equivocal conclusions have been reached with respect to the effects of UV-B on amphibian populations. Field and laboratory studies employing both ecologically relevant and enhanced UV-B levels have been conducted using a variety of amphibian species and reports differ with respect to the most sensitive developmental stage and the ultimate implications. UV-B radiation has also been shown to interact with other stressors (e.g., pesticides, polycyclic aromatic hydrocarbons, low pH) resulting in decreased survivorship for several amphibian species. Limited evidence of reproductive toxicity of xenobiotics in amphibians exist; however, early exposure to EDCs could cause abnormal development of the amphibian reproductive system, inhibit vital hormone messages that drive metamorphosis, and ultimately contribute to the decline of some amphibian populations. The available evidence suggests that more than one agent is contributing to amphibian population declines and the following review narrows the focus to address the existing data on the effects of UV-B, alone and in combination with other stressors, and EDCs on amphibian survivorship and development. Key words: amphibians, UV-B radiation, endocrine-disrupting chemicals, declines, review.

Elvira V Bräuner ◽  
Youn-Hee Lim ◽  
Trine Koch ◽  
Cecilie S Uldbjerg ◽  
Laura S Gregersen ◽  

Abstract The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.

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