Platelet-rich plasma. Evidenze, limiti e prospettive future

Abstract Regenerative medicine is a promising frontier in several fields of medicine and surgery. In orthopaedics, cell products are used to facilitate the regeneration of bone, tendons, and cartilage in many orthopaedic disorders. A large portion of scientific literature is developing while basic science provides further information on tissue healing and the biological pathways to enhance it. PRP is one of the most promising products used as biological therapy. Even though a standardised methodology of preparation and utilisation is still missing, promising results coming from clinical research encourage its use. Further research will meet the challenge of standardising procedures, timing and way of application, and outcomes reporting, so as to allow researcher to make analyses and comparisons that will expand our knowledge of this interesting field of medicine.

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Scientific Evidence of Platelet-Rich Plasma for Orthopedic Conditions: Basic Science to Clinical Research and Application

Regenerative Treatments in Sports and Orthopedic Medicine ◽

10.1891/9781617052897.0007 ◽

2017 ◽

Author(s):

Peter I-Kung Wu ◽

Robert Diaz ◽

Joanne Borg-Stein

Keyword(s):

Clinical Research ◽

Basic Science ◽

Platelet Rich Plasma ◽

Scientific Evidence

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Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region

Oral Science International ◽

10.1016/s1348-8643(14)00008-1 ◽

2014 ◽

Vol 11 (2) ◽

pp. 45-51 ◽

Cited By ~ 9

Author(s):

Tsuyoshi Takato ◽

Yoshiyuki Mori ◽

Yuko Fujihara ◽

Yukiyo Asawa ◽

Satoru Nishizawa ◽

...

Keyword(s):

Regenerative Medicine ◽

Clinical Research ◽

Maxillofacial Region ◽

Oral And Maxillofacial Region ◽

And Cartilage

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Biologic Association Annual Summit: 2020 Report

Orthopaedic Journal of Sports Medicine ◽

10.1177/23259671211015667 ◽

2021 ◽

Vol 9 (6) ◽

pp. 232596712110156

Author(s):

Rachel M. Frank ◽

Seth L. Sherman ◽

Jorge Chahla ◽

Jason L. Dragoo ◽

Bert Mandelbaum ◽

...

Keyword(s):

Randomized Clinical Trials ◽

Biological Therapy ◽

Platelet Rich Plasma ◽

Therapy Outcomes ◽

Preclinical Research ◽

Scientific Societies ◽

Tissue Healing ◽

Lay Understanding ◽

Processing Techniques ◽

Made In

Interest and research in biologic approaches for tissue healing are exponentially growing for a variety of musculoskeletal conditions. The recent hype concerning musculoskeletal biological therapies (including viscosupplementation, platelet-rich plasma, and cellular therapies, or “stem cells”) is driven by several factors, including demand by patients promising regenerative evidence supported by substantial basic and translational work, as well as commercial endeavors that complicate the scientific and lay understanding of biological therapy outcomes. While significant improvements have been made in the field, further basic and preclinical research and well-designed randomized clinical trials are needed to better elucidate the optimal indications, processing techniques, delivery, and outcome assessment. Furthermore, biologic treatments may have potential devastating complications when proper methods or techniques are ignored. For these reasons, an association comprising several scientific societies, named the Biologic Association (BA), was created to foster coordinated efforts and speak with a unified voice, advocating for the responsible use of biologics in the musculoskeletal environment in clinical practice, spearheading the development of standards for treatment and outcomes assessment, and reporting on the safety and efficacy of biologic interventions. This article will introduce the BA and its purpose, provide a summary of the 2020 first annual Biologic Association Summit, and outline the future strategic plan for the BA.

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Neural Mechanisms of Fear in PTSD: Moving from Basic Science to Clinical Research

PsycEXTRA Dataset ◽

10.1037/e533652013-153 ◽

2012 ◽

Author(s):

Yuval Neria ◽

Roger Pitman

Keyword(s):

Clinical Research ◽

Basic Science ◽

Neural Mechanisms

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Bridging the divide: The widening gap between basic science and clinical research

Translational Research in Anatomy ◽

10.1016/j.tria.2021.100117 ◽

2021 ◽

Vol 24 ◽

pp. 100117

Author(s):

Matthew Carvey ◽

Woong Kee Baek ◽

Robert Hage

Keyword(s):

Clinical Research ◽

Basic Science

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Systematic review of clinical research on regenerative medicine for the cornea

Japanese Journal of Ophthalmology ◽

10.1007/s10384-021-00821-z ◽

2021 ◽

Vol 65 (2) ◽

pp. 169-183

Author(s):

Yoshinori Oie ◽

Shimpei Komoto ◽

Ryo Kawasaki

Keyword(s):

Systematic Review ◽

Regenerative Medicine ◽

Clinical Research

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Enhanced regeneration of bone defects using sintered porous Ti6Al4V scaffolds incorporated with mesenchymal stem cells and platelet-rich plasma

RSC Advances ◽

10.1039/d0ra10215f ◽

2021 ◽

Vol 11 (9) ◽

pp. 5128-5138

Author(s):

Ji Li ◽

Ketao Wang ◽

Xiaowei Bai ◽

Qi Wang ◽

Ningyu Lv ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bone Regeneration ◽

Platelet Rich Plasma ◽

Bone Defects ◽

Regeneration Of Bone

Porous Ti6AI4V scaffolds incorporated with MSC and PRP are more effective in enhancing the bone regeneration.

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Poly-(lactic acid) and fibrin bioactive cellularized scaffold for use in bone regenerative medicine: Proof of concept

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911521996402 ◽

2021 ◽

pp. 088391152199640

Author(s):

Renata Aquino de Carvalho ◽

Valmir Vieira Rocha Júnior ◽

Antonio José Felix Carvalho ◽

Heloisa Sobreiro Selistre de Araújo ◽

Mônica Rosas Costa Iemma ◽

...

Keyword(s):

Lactic Acid ◽

Regenerative Medicine ◽

Platelet Rich Plasma ◽

Three Dimensional ◽

Culture Conditions ◽

Infrapatellar Fat Pad ◽

Dimensional Structure ◽

Poly Lactic Acid ◽

Proof Of Concept ◽

Critical Bone Defects

Bone regenerative medicine (BRM) aims to overcome the limitations of conventional treatments for critical bone defects by developing therapeutic strategies, based on temporary bioactive substitutes, capable of stimulating, sustaining, and guiding tissue regeneration. The aim of this study was to validate the “proof of concept” of a cellularized bioactive scaffold and establish its potential for use in BRM. For this purpose, three-dimensional scaffolds of poly-(lactic acid) (PLA), produced by the additive manufacturing technique, were incorporated into a human platelet-rich plasma (PRP-h) fibrin matrix containing human infrapatellar fat pad mesenchymal stem cells (hIFPMSC). The scaffolds (PLA/finbrin-bioactive) were kept under ideal culture conditions in a medium free from fetal bovine serum and analyzed at 5 and 10 days by Scanning Electron Microscopy (SEM), Fourrier Transform Infrared (FTIR), Circular Dichroism and fluorescence microscopy. The results demonstrated the feasibility of obtaining a rigid, cytocompatible, and cellularized three-dimensional structure. In addition, PRP platelets and leukocytes were able to provide a bioactive environment capable of maintaining the viability of hIFPMSC into scaffolds. The results validate the concept of a customizable, bioactive, cellularized, and non-immunogenic strategy for application in BRM.

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