Objectives: Guillain-Barre Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy characterized by rapidly progressive paresis and sensory disturbances. Laparoscopic Sleeve Gastrectomy (LSG), used of morbid obesity, is the standard surgical treatment method for Bariatric Surgery (BS). Neurological complications of BS are also increasing with growing obesity prevalence. We present a case of developed acute polyneuropathy after BS. Study Design-Methods: The presentation of GBS is ascending paralysis, reduction/loss of muscle stretch reflexes, and albumino-cytologic dissociation in the CSF. The diagnosis was made using anamnesis, neurological examination, Electroneuromyography (ENMG) and laboratory findings. Results: Neurological complications of BS are usually related to micronutrients deficiencies secondary to malabsorbtion after surgery. The complications are seen variable which are count encephalopathy, optic neuropathy, myelopathy, polyradiculoneuropathy, and polyneuropathy. Conclusions: Among these, GBS appears to be a very rare complication in BS. It is important to consider the diagnosis of peripheral neuropathy, and discrimination of GuillainBarré syndrome. Because of, their treatments are different.