This chapter traces the history of music and philosophy in the Enlightenment, with a particular focus on English thinkers in the years 1660–1750. It identifies three modes of interaction between musical and philosophical ideas: music as object of philosophy, music as inspiration for philosophy, and music as corroboration for philosophy. The chapter hones in particularly on the significance of the new, “mechanical” approach to philosophy that emerged in the later seventeenth century and on changing explanations of music’s fabled ability to cure the bite of the tarantula. Through all of this, it uncovers how ideas about musical harmony and music’s affective power were intertwined in this period. It also includes two eighteenth-century case studies showing how these ideas played themselves out in the French “high” Enlightenment and in German Idealist philosophy at the close of the Enlightenment. The chapter closes with an examination of the relative merits, in this context, of the terms “Baroque,” “scientific revolution,” and “Enlightenment.”