Physicochemical characterization and dissolution enhancement of loratadine by solid dispersion technique

2013 ◽  
Vol 30 (1) ◽  
pp. 238-244 ◽  
Author(s):  
Suresh Bandari ◽  
Subash Jadav ◽  
Basanth Babu Eedara ◽  
Raju Jukanti ◽  
Prabhakar Reddy Veerareddy
Keyword(s):  
Solid Dispersion ◽  
Physicochemical Characterization ◽  
Dissolution Enhancement ◽  
Dispersion Technique

scholarly journals Dissolution Enhancement of Fenofibrate by Solid Dispersion Technique

2011 ◽  
Vol 1 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Patel Tejas . ◽  
Patel L.D . ◽  
Adeshara S. P . ◽  
Patel Timir . ◽  
Makwana Sunil . ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Dissolution Enhancement ◽  
Dispersion Technique

scholarly journals Physicochemical Characterization and Dissolution Enhancement of Bilastine by Solid Dispersion

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Sanjesh G. Rathi ◽  
Dhruv B. Chaudhari
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Solvent Evaporation ◽  
Dissolution Enhancement ◽  
Solvent Evaporation Method ◽  
In Vitro Drug Release ◽  
Evaporation Method ◽  
Pvp K30

The solid dispersions of Bilastine with HPMC, PVP K30 and HPC have been prepared in different weight ratios by using solvent evaporation method. DSC was used to characterize the samples of solid dispersions and pure drug. Drug found compatible with the excipients. The highest improvements in solubility and in-vitro drug release were observed in solid dispersion prepared with HPC (F14) by solvent evaporation method. The increased dissolution rate of drug from solid dispersion may be due to surface tension lowering effect of polymer to the medium and increased wettability and dispersibility of drug. Hence, F14 Solid dispersion with the HPC carrier considered as most satisfactory among all solid dispersions.

scholarly journals Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407

2009 ◽  
Vol 59 (4) ◽  
pp. 453-461 ◽  
Author(s):  
Vikrant Vyas ◽  
Pankajkumar Sancheti ◽  
Poonam Karekar ◽  
Manali Shah ◽  
Yogesh Pore
Keyword(s):  
Solid Dispersion ◽  
Binary Systems ◽  
Physicochemical Characterization ◽  
Water Soluble ◽  
Poloxamer 407 ◽  
Dissolution Enhancement ◽  
Water Soluble Drug ◽  
Dispersion Systems ◽  
Rapid Dissolution

Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407 Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 ± 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug, indicating altered rheological characteristics of the polymer at its higher concentration, which might have retarded the release rate of tadalafil.

scholarly journals Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique

2021 ◽  
Vol 30 (1) ◽  
pp. 122-132
Author(s):  
Lna S. Hussein ◽  
Eman B. H. Al-Khedairy
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Water Solubility ◽  
Chemical Interaction ◽  
Drug Carrier ◽  
Dissolution Enhancement ◽  
Duration Of Action ◽  
Drug Content ◽  
Percentage Yield ◽  
Dispersion Technique

Ebastine (EBS) is a non-sedating antihistamine with a long duration of action. This drug has predominantly hydrophobic property causing a low solubility and low bioavailability. Surface solid dispersions (SSD) is an effective technique for improving the solubility and dissolution rate of poorly soluble drugs by using hydrophilic water insoluble carriers. The present study aims to enhance the solubility and dissolution rate of EBS by using surface solid dispersion technique. Avicel® PH101, Avicel® PH 102, croscarmellose sodium(CCS) and sodium starch glycolate(SSG) were used as water insoluble hydrophilic carriers. The SSD formulations of EBS were prepared by the solvent evaporation method in different drug:  carrier weight ratios and evaluated for their percentage yield, drug content , water solubility, dissolution study in 0.1 N HCl, crystal lattice using powder  X-ray diffraction (PXRD) and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier interaction. Most of the prepared SSD formulas showed improvement of drug solubility. The best result was obtained with formula SSD16 (EBS:CCS 1:15) that showed high percentage yield (98.5%), high drug content (98.39%) and 8.2 fold increase in solubility compared to solubility of pure drug with improved dissolution rate. The drug was converted to amorphous form without chemical interaction with the carrier.

scholarly journals SOLUBILITY AND DISSOLUTION ENHANCEMENT OF PIOGLITAZONE USING SOLID DISPERSION TECHNIQUE

2017 ◽  
pp. 186-193
Author(s):  
Bhushan A. Bhairav ◽  
Lalit R. Jagtap ◽  
R. B. Saudagar
Keyword(s):  
Solid Dispersion ◽  
Chemical Interaction ◽  
Physicochemical Characteristics ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Hydrophobic Drug ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Dispersion Technique ◽  
Poorly Water Soluble Drug

Objective: To design the study to improve the solubility and hence enhance the dissolution of hydrophobic drug Pioglitazone in order to increase its bioavailability.Methods: Solid dispersion of Pioglitazone using carriers Poloxomer 188 and HPβCD was formulated in different ratios by microwave induced fusion method. In particular, the Microwave technology has been considered in order to prepare an enhanced release dosage form for poorly water soluble drug Pioglitazone. Statistical Analysis: Their physicochemical characteristics and solubility were compared to the corresponding dispersions and marketed drug. Drug and polymer were further characterized by FTIR.Results: The results of FTIR revealed that no chemical interaction between the drug and the polymer exist.Conclusion: All the formulations showed a marked increase in drug release with the increase in the concentration of Poloxomer 188 and HPβCD. 

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