Options for the Treatment of Mucinous Ovarian Carcinoma

2021 ◽  
Vol 22 (12) ◽  
Author(s):  
Olivia Craig ◽  
Carolina Salazar ◽  
Kylie L. Gorringe
Keyword(s):  
Ovarian Carcinoma ◽  
Mucinous Ovarian Carcinoma

Safety of fertility sparing management in invasive mucinous ovarian carcinoma

2021 ◽  
Vol 162 ◽  
pp. S269-S270
Author(s):  
Rachel Soyoun Kim ◽  
Ainhoa Madariaga ◽  
Liat Hogen ◽  
Danielle Vicus ◽  
Allan Covens ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Fertility Sparing ◽  
Mucinous Ovarian Carcinoma

scholarly journals High frequency of BRAF mutations in primary mucinous ovarian carcinoma of Taiwanese patients

2021 ◽  
Vol 60 (6) ◽  
pp. 1072-1077
Author(s):  
Wan-Ru Chao ◽  
Yi-Ju Lee ◽  
Ming-Yung Lee ◽  
Gwo-Tarng Sheu ◽  
Chih-Ping Han
Keyword(s):  
Ovarian Carcinoma ◽  
High Frequency ◽  
Braf Mutations ◽  
Mucinous Ovarian Carcinoma

Adjuvant chemotherapy is not associated with a survival benefit for patients with early stage mucinous ovarian carcinoma

2019 ◽  
Vol 154 (2) ◽  
pp. 302-307 ◽  
Author(s):  
Dimitrios Nasioudis ◽  
Ashley F. Haggerty ◽  
Robert L. Giuntoli ◽  
Robert A. Burger ◽  
Mark A. Morgan ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ovarian Carcinoma ◽  
Survival Benefit ◽  
Early Stage ◽  
Mucinous Ovarian Carcinoma

Abstract 3283: GWAS identifies risk variants for mucinous ovarian carcinoma

2014 ◽  
Author(s):  
Linda E. Kelemen ◽  
Jonathan Tyrer ◽  
Catherine M. Phelan ◽  
Susan J. Ramus ◽  
Andrew Berchuck ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Risk Variants ◽  
Mucinous Ovarian Carcinoma

Comprehensive genomic profiling of mucinous ovarian carcinoma with comparisons to mucinous colorectal carcinoma

2019 ◽  
Vol 154 ◽  
pp. 63
Author(s):  
N.L. Jones ◽  
D. Arguello ◽  
R.W. Holloway ◽  
T.J. Herzog ◽  
A.C. ElNaggar ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Ovarian Carcinoma ◽  
Genomic Profiling ◽  
Comprehensive Genomic Profiling ◽  
Mucinous Ovarian Carcinoma

scholarly journals Mucinous ovarian carcinoma: Slippery business

Cancer ◽  
2010 ◽  
Vol 117 (3) ◽  
pp. 451-453 ◽  
Author(s):  
Robert A. Soslow
Keyword(s):  
Ovarian Carcinoma ◽  
Mucinous Ovarian Carcinoma

Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma

2018 ◽  
Vol 26 (4) ◽  
pp. 306-317 ◽  
Author(s):  
Dina Bassiouny ◽  
Nadia Ismiil ◽  
Valerie Dubé ◽  
Guangming Han ◽  
Matthew Cesari ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Advanced Disease ◽  
Mucinous Carcinoma ◽  
Therapeutic Options ◽  
Clinicopathologic Features ◽  
Napsin A ◽  
Mucinous Ovarian Carcinoma ◽  
Mmr Proteins ◽  
Her2 Positivity

The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11.1%). P53 was aberrant in 10 (27.8%); none overexpressed p16. HER2 was positive in 6/35 (17.1%). Most PMOCs had a favorable outcome. However, recurrence is usually fatal. The typical tumor profile was CK7+, CK20+/−, CDX2+/−, PAX8−, ER−, PgR−, and SATB2−. HER2 positivity suggests a possible target for therapy in advanced disease.

scholarly journals Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Georgina L. Ryland ◽  
◽  
Sally M. Hunter ◽  
Maria A. Doyle ◽  
Franco Caramia ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Mutational Landscape ◽  
Mucinous Ovarian Carcinoma

Aggressive anaplastic ovarian carcinoma in a young nulliparous patient

2021 ◽  
Vol 14 (4) ◽  
pp. e241461
Author(s):  
Alicia Hunter ◽  
Susan Addley ◽  
Hooman Soleymani majd
Keyword(s):  
Ovarian Carcinoma ◽  
Anaplastic Carcinoma ◽  
Optimal Management ◽  
Ovarian Mass ◽  
Debulking Surgery ◽  
Primary Debulking Surgery ◽  
Ovarian Tumours ◽  
Sister Mary Joseph ◽  
Mucinous Ovarian Carcinoma ◽  
Mural Nodules

Ovarian tumours harbouring foci of anaplastic carcinoma are extremely rare. With just a handful of cases reported in the literature, understanding of the disease and optimal management remains limited. A 38-year-old woman was referred to the gynaeoncologists with a multiloculated complex ovarian mass. High-grade mucinous ovarian carcinoma with mural nodules of anaplastic carcinoma was found on biopsy. Furthermore, an umbilical Sister Mary Joseph nodule signalled advanced metastatic disease. The patient underwent primary debulking surgery and was referred for adjuvant chemotherapy. High-quality radiological and surgical images are included to illustrate the approach taken to preoperative diagnosis and described surgical technique. Our case demonstrates the aggressive and rapidly progressive nature of mucinous ovarian carcinoma bearing anaplastic components. Sharing experience of such cases generates awareness and highlights the need for early detection and thorough investigations to guide subsequent management.

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