The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression

2006 ◽  
Vol 8 (6) ◽  
pp. 452-457 ◽  
Author(s):  
Derick E. Vergne ◽  
Charles B. Nemeroff
Keyword(s):  
Major Depression ◽  
Life Events ◽  
Serotonin Transporter ◽  
Gene Polymorphisms ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Adverse Life Events

scholarly journals Life events, first depression onset and the serotonin transporter gene

2006 ◽  
Vol 188 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Kay Wilhelm ◽  
Philip B. Mitchell ◽  
Heather Niven ◽  
Adam Finch ◽  
Lucinda Wedgwood ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depression ◽  
Life Events ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Adverse Life Events ◽  
Gene Environment Interaction ◽  
Gene Environment

BackgroundA relationship between the serotonin transporter gene, adverse events and onset of major depression has been reported.AimsTo replicate a gene × environment interaction in a cohort with longitudinal data for life events, experience of depression, parental bonding and neuroticism.MethodAtthe 25-year follow-up, genomic DNA was obtained from 127 cohort members (mean age 48 years) to determine the genotype of the serotonin transporter gene-linked promoter region (5-HTTLPR). Associations were investigated between the 5-HTTLPR genotype, positive and adverse life events and the gene × environment interaction, and also between the 5-HTTLPR genotype and risk factors for depression.ResultsNo relationship was found between 5-HTTLPR genotype and either risk factors for depression or positive life events. Adverse life events had a significantly greater impact on the onset of depression for individuals with the s/s genotype.ConclusionsThe 5-HTTLPR genotype is a significant predictor of onset of major depression following multiple adverse events. This is one of the more robust findings concerning specific biological risk factors for depression.

Adverse Life Events and Allele-Specific Methylation of the Serotonin Transporter Gene (SLC6A4) in Adolescents

2015 ◽  
Vol 77 (3) ◽  
pp. 246-255 ◽  
Author(s):  
Lisette J. van der Knaap ◽  
Harriëtte Riese ◽  
James J. Hudziak ◽  
Michael M.P.J. Verbiest ◽  
Frank C. Verhulst ◽  
...  
Keyword(s):  
Life Events ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Adverse Life Events ◽  
Allele Specific ◽  
Allele Specific Methylation

Serotonin Transporter Gene Polymorphisms and Sertraline Response in Major Depression Patients

2008 ◽  
Vol 12 (2) ◽  
pp. 225-231 ◽  
Author(s):  
Ozlem Dogan ◽  
Nevzat Yuksel ◽  
Mehmet Ali Ergun ◽  
Akin Yilmaz ◽  
Mustafa N. Ilhan ◽  
...  
Keyword(s):  
Major Depression ◽  
Serotonin Transporter ◽  
Gene Polymorphisms ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

P.1.24 Serotonin transporter gene and adverse life events in adult ADHD

2008 ◽  
Vol 18 ◽  
pp. s21
Author(s):  
L. Mandelli ◽  
D.J. Müller ◽  
A. Serretti ◽  
C.G. De Young ◽  
V. De Luca ◽  
...  
Keyword(s):  
Life Events ◽  
Serotonin Transporter ◽  
Adult Adhd ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Adverse Life Events

Serotonin transporter gene and adverse life events in adult ADHD

2008 ◽  
Vol 147B (8) ◽  
pp. 1461-1469 ◽  
Author(s):  
Daniel J. Müller ◽  
Laura Mandelli ◽  
Alessandro Serretti ◽  
Colin G. DeYoung ◽  
Vincenzo De Luca ◽  
...  
Keyword(s):  
Life Events ◽  
Serotonin Transporter ◽  
Adult Adhd ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Adverse Life Events

Serotonin transporter gene and adverse life events in adult ADHD

2008 ◽  
Vol 23 ◽  
pp. S174
Author(s):  
L. Mandelli ◽  
D.J. Muller ◽  
A. Serretti ◽  
C.G. DeYoung ◽  
V. De luca ◽  
...  
Keyword(s):  
Life Events ◽  
Serotonin Transporter ◽  
Adult Adhd ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Adverse Life Events
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