The Organogermanium Compound Ge-132 Interacts with Nucleic Acid Components and Inhibits the Catalysis of Adenosine Substrate by Adenosine Deaminase

Biological Trace Element Research ◽

10.1007/s12011-017-1020-4 ◽

2017 ◽

Vol 181 (1) ◽

pp. 164-172 ◽

Author(s):

Yasuhiro Shimada ◽

Katsuyuki Sato ◽

Tomoya Takeda ◽

Yoshihiko Tokuji

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Organogermanium Compound

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ChemInform Abstract: Nucleic Acid Related Compounds. Part 114. Synthesis of 2,6-(Disubstituted)purine 2′,3′-Dideoxynucleosides [cf. (V)] and Selected Cytotoxic, Anti-Hepatitis B, and Adenosine Deaminase Substrate Activities.

10.1002/chin.200217213 ◽

2010 ◽

Vol 33 (17) ◽

pp. no-no

Author(s):

Morris J. Robins ◽

John S. Wilson ◽

Danuta Madej ◽

D. Lorne J. Tyrrell ◽

Wendy P. Gati ◽

...

Keyword(s):

Nucleic Acid ◽

Hepatitis B ◽

Adenosine Deaminase ◽

Related Compounds

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ChemInform Abstract: Nucleic Acid Related Compounds. Part 48. Photoaddition of Methanol to 9-(β-D- Ribofuranosyl)purine (Nebularine) to give Inhibitors of Adenosine Deaminase.

Chemischer Informationsdienst ◽

10.1002/chin.198602322 ◽

1986 ◽

Vol 17 (2) ◽

Author(s):

D. K. BUFFEL ◽

C. MCGUIGAN ◽

M. J. ROBINS

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Related Compounds

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ChemInform Abstract: Nucleic Acid Related Compounds. Part 82. Conversions of Adenosine to Inosine 5′-Thioether Derivatives with Aspergillus oryzae Adenosine Deaminase or Alkyl Nitrites. Substrate and Inhibitory Activities of Inosine 5′-Thioether Derivativ

10.1002/chin.199502185 ◽

2010 ◽

Vol 26 (2) ◽

pp. no-no

Author(s):

S. F. WNUK ◽

J. D. STOECKLER ◽

M. J. ROBINS

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Aspergillus Oryzae ◽

Alkyl Nitrites ◽

Inhibitory Activities ◽

Related Compounds

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Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis b, and adenosine deaminase substrate activities

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570380609 ◽

2001 ◽

Vol 38 (6) ◽

pp. 1297-1306 ◽

Author(s):

Morris J. Robins ◽

R. J. Lindmark ◽

Stanislaw F. Wnukt ◽

John S. Wilson ◽

Danuta Madej ◽

...

Keyword(s):

Nucleic Acid ◽

Hepatitis B ◽

Adenosine Deaminase ◽

Related Compounds

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ChemInform Abstract: NUCLEIC ACID RELATED COMPOUNDS PART 8, DIRECT CONVERSION OF 2′-DEOXYINOSINE TO 6-CHLOROPURINE 2′-DEOXYRIBOSIDE AND SELECTED 6-SUBSTITUTED DEOXYNUCLEOSIDES AND THEIR EVALUATION AS SUBSTRATES OF ADENOSINE DEAMINASE

Chemischer Informationsdienst ◽

10.1002/chin.197403416 ◽

1974 ◽

Vol 5 (3) ◽

pp. no-no

Author(s):

MORRIS J. ROBINS ◽

GERALD L. BASOM

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Direct Conversion ◽

Related Compounds

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Double-Stranded RNA-Specific Adenosine Deaminase: Nucleic Acid Binding Properties

Methods ◽

10.1006/meth.1998.0624 ◽

1998 ◽

Vol 15 (3) ◽

pp. 199-205 ◽

Author(s):

Yong Liu ◽

Alan Herbert ◽

Alexander Rich ◽

Charles E. Samuel

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Nucleic Acid Binding ◽

Binding Properties ◽

Double Stranded Rna

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ChemInform Abstract: Nucleic Acid Related Compounds. Part 96. Synthesis of Sugar-Modified 2, 6-Diaminopurine and Guanine Nucleosides from Guanosine via Transformations of 2-Aminoadenosine and Enzymatic Deamination with Adenosine Deaminase.

10.1002/chin.199752245 ◽

2010 ◽

Vol 28 (52) ◽

pp. no-no

Author(s):

M. J. ROBINS ◽

R. ZOU ◽

F. HANSSKE ◽

S. F. WNUK

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Related Compounds

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Combination of adenosine-deaminase and nucleic acid amplification assays for diagnosing tuberculous pleural effusion

Journal of Infection ◽

10.1016/j.jinf.2014.03.004 ◽

2014 ◽

Vol 69 (1) ◽

pp. 99-101 ◽

Author(s):

Sunil Sethi ◽

Jaspreet Kaur ◽

Rakesh Yadav ◽

Sunil Kumar Dhatwalia ◽

Abhishek Mewara ◽

...

Keyword(s):

Nucleic Acid ◽

Pleural Effusion ◽

Adenosine Deaminase ◽

Nucleic Acid Amplification ◽

Tuberculous Pleural Effusion

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Nucleic acid related compounds. 48. Photoaddition of methanol to 9-(.beta.-D-ribofuranosyl) purine (nebularine) to give inhibitors of adenosine deaminase.

The Journal of Organic Chemistry ◽

10.1021/jo00215a014 ◽

1985 ◽

Vol 50 (15) ◽

pp. 2664-2667 ◽

Author(s):

Diederik K. Buffel ◽

Christopher McGuigan ◽

Morris J. Robins

Keyword(s):

Nucleic Acid ◽

Adenosine Deaminase ◽

Related Compounds

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Introduction

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100070266 ◽

1978 ◽

Vol 36 (3) ◽

pp. 543-544

Author(s):

W. Bernard

Keyword(s):

Molecular Weight ◽

Electron Microscope ◽

Nucleic Acid ◽

Gene Mapping ◽

Molecular Genetics ◽

Cell Biology ◽

Gene Activity ◽

Close Connection ◽

Basic Information ◽

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

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