The Neuroprotective Effects of Isoflurane Preconditioning in a Murine Transient Global Cerebral Ischemia–Reperfusion Model: The Role of the Notch Signaling Pathway

2013 ◽  
Vol 16 (1) ◽  
pp. 191-204 ◽  
Author(s):  
Hao-peng Zhang ◽  
Yan-yan Sun ◽  
Xiao-mei Chen ◽  
Li-bang Yuan ◽  
Bin-xiao Su ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Ischemia Reperfusion ◽  
Notch Signaling Pathway ◽  
Global Cerebral Ischemia ◽  
Neuroprotective Effects ◽  
Transient Global Cerebral Ischemia ◽  
Cerebral Ischemia Reperfusion

Neuroprotective Effects of Alisol A 24-acetate on Cerebral Ischemia-reperfusion Injury by Regulating PI3K/AKT Pathway

2021 ◽  
Author(s):  
Taotao Lu ◽  
Huihong Li ◽  
Yangjie Zhou ◽  
Wei Wei ◽  
Linlin Ding ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion ◽  
Brain Regions ◽  
Global Cerebral Ischemia ◽  
Akt Pathway ◽  
Object Recognition Test ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia Reperfusion

Abstract BackgroundNeuroinflammation and apoptosis are involved in the pathogenesis of ischemic stroke. Alisol A 24-acetate (24A) has a strong inhibitory effect on inflammation and cell apoptosis. The neuroprotective effect of 24A in the global cerebral ischemia/ reperfusion (GCI/R) is still unclear. Methods GCI/R mice was used to investigated the neuroprotective effect of 24A. Modified neurological deficit scores, Morris Water Maze and object recognition test were used to evaluate behaviors. The metabolism in brain regions was detected by MRS. The changes of microglia, astrocytes and neurons was detected. The inflammation and apoptosis were measured.Results The results showed that 24A improved behavioral dysfunction and brain metabolism, alleviate neuroinflammation and apoptosis, inhibited microglia and astrocytes activation, which is associated with the activation of PI3K/AKT pathway. ConclusionsTaken together, our study demonstrated that 24A could alleviate GCI/R injury through anti-neuroinflammation and anti-apoptosis via regulating the PI3K/AKT pathway.

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