scholarly journals Differential blood leukocyte populations based on individual variances and age

2022 ◽  
Author(s):  
Jane Kasten-Jolly ◽  
David A. Lawrence
Keyword(s):  
Blood Leukocyte ◽  
Leukocyte Populations

scholarly journals Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations

Allergy ◽  
2020 ◽  
Author(s):  
Bernhard Kratzer ◽  
Doris Trapin ◽  
Paul Ettel ◽  
Ulrike Körmöczi ◽  
Arno Rottal ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Blood Leukocyte ◽  
Leukocyte Populations

Effect of mycophenolate mofetil therapy on the phenotypic profile of peripheral blood leukocyte populations in psoriatic patients

2010 ◽  
Vol 20 (2) ◽  
pp. 233-234
Author(s):  
Esteban Daudén ◽  
Javier Pedraz ◽  
Silvia Pérez-Gala ◽  
Cecilia Muñoz ◽  
Manuel Vitón ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Phenotypic Profile ◽  
Blood Leukocyte ◽  
Leukocyte Populations

scholarly journals Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

Blood ◽  
1994 ◽  
Vol 84 (4) ◽  
pp. 1201-1208 ◽  
Author(s):  
K Iwai ◽  
T Miyawaki ◽  
T Takizawa ◽  
A Konno ◽  
K Ohta ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Peripheral Blood Lymphocytes ◽  
Apoptotic Cell Death ◽  
Cell Surface Molecule ◽  
Cellular Survival ◽  
Blood Leukocyte ◽  
Leukocyte Populations ◽  
Monocytes And Lymphocytes

The recently identified Fas antigen (Ag) is a cell surface molecule that can mediate apoptosis. The cytoplasmic product of proto-oncogene bcl-2 has been shown to prolong the cellular survival by inhibiting apoptosis. To elucidate the physiologic significance of expression of both molecules, we examined the expression of Fas Ag and bcl-2 on blood leukocyte populations and evaluated their sensitivity to the cytolytic action of anti-Fas antibody. Although Fas Ag was expressed on a fraction of lymphocytes, both neutrophils and monocytes expressed Fas Ag constitutively. In contrast, there was marked difference among these leukocytes regarding bcl-2 expression. Lymphocytes expressed bcl-2 intensely, but monocytes showed weaker bcl-2 expression, and neutrophils were essentially absent for bcl-2 expression. Seemingly reflecting this lack of bcl-2-expression, neutrophils more easily underwent apoptotic cell death in vitro as compared with monocytes and lymphocytes. We showed that anti-Fas antibody affectively accelerated apoptotic cell death in neutrophils. However, the apoptosis-inducing effect of anti-Fas antibody was minimal on monocytes, and lymphocytes were resistant to this antibody. These results suggest that anti-Fas- mediated cell death may, in part, be determined by bcl-2 expression status in Fas+ lymphoid and hematopoietic cells.

scholarly journals Peripheral Blood Leukocyte Populations in Dairy Cows Infected with Bovine Leukemia Virus

2011 ◽  
Vol 64 (5) ◽  
pp. 375-380 ◽  
Author(s):  
Seiichi KAKINUMA ◽  
Hiromichi OHTSUKA ◽  
Kaori OHMAE ◽  
Kyouko AYABE ◽  
Motoharu KAKINUMA ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Peripheral Blood ◽  
Bovine Leukemia Virus ◽  
Leukemia Virus ◽  
Peripheral Blood Leukocyte ◽  
Blood Leukocyte ◽  
Leukocyte Populations

scholarly journals Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

Blood ◽  
1994 ◽  
Vol 84 (4) ◽  
pp. 1201-1208 ◽  
Author(s):  
K Iwai ◽  
T Miyawaki ◽  
T Takizawa ◽  
A Konno ◽  
K Ohta ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Peripheral Blood Lymphocytes ◽  
Apoptotic Cell Death ◽  
Cell Surface Molecule ◽  
Cellular Survival ◽  
Blood Leukocyte ◽  
Leukocyte Populations ◽  
Monocytes And Lymphocytes

Abstract The recently identified Fas antigen (Ag) is a cell surface molecule that can mediate apoptosis. The cytoplasmic product of proto-oncogene bcl-2 has been shown to prolong the cellular survival by inhibiting apoptosis. To elucidate the physiologic significance of expression of both molecules, we examined the expression of Fas Ag and bcl-2 on blood leukocyte populations and evaluated their sensitivity to the cytolytic action of anti-Fas antibody. Although Fas Ag was expressed on a fraction of lymphocytes, both neutrophils and monocytes expressed Fas Ag constitutively. In contrast, there was marked difference among these leukocytes regarding bcl-2 expression. Lymphocytes expressed bcl-2 intensely, but monocytes showed weaker bcl-2 expression, and neutrophils were essentially absent for bcl-2 expression. Seemingly reflecting this lack of bcl-2-expression, neutrophils more easily underwent apoptotic cell death in vitro as compared with monocytes and lymphocytes. We showed that anti-Fas antibody affectively accelerated apoptotic cell death in neutrophils. However, the apoptosis-inducing effect of anti-Fas antibody was minimal on monocytes, and lymphocytes were resistant to this antibody. These results suggest that anti-Fas- mediated cell death may, in part, be determined by bcl-2 expression status in Fas+ lymphoid and hematopoietic cells.

Increased Tissue Factor Activity Generation In Vitro by Canine Blood Leukocytes Associated with Allogeneic Kidney Transplantation and Rejection

1985 ◽  
Vol 53 (01) ◽  
pp. 001-004 ◽  
Author(s):  
Henry Rothberger ◽  
Jesse Meredith ◽  
Tom Mutton ◽  
Jeffery Brown ◽  
Maria P McGee
Keyword(s):  
Kidney Transplantation ◽  
Tissue Factor ◽  
Canine Model ◽  
Blood Leukocytes ◽  
Kidney Rejection ◽  
Blood Leukocyte ◽  
Leukocyte Populations ◽  
Kidney Allotransplantation

SummaryUsing a canine model, leukocyte populations enriched for monocytes and lymphocytes were isolated from blood during three week periods after kidney allotransplantation corresponding to episodes of acute rejection. Relative to controls, these cells incubated in vitro for five hours were found to generate increased amounts of PCA (procoagulant activity) characterized as tissue factor, the extrinsic clotting pathway activator. Controls included comparable blood leukocyte populations isolated from kidney autograft recipients and healthy animals. Differences in results for these two control groups were insignificant. These contrasts observed between allografted animals and controls demonstrate that leukocyte PCA generation is stimulated by the allogeneicity of histoincompatible kidneys rather than by direct effects of organ transplantation or non-specific postoperative effects. Results of in vitro transfer experiments provide evidence that cellular stimulation or induction in vivo accounted for the PCA increases observed. Stimulation of leukocyte tissue factor generation as a consequence of allogeneic kidney transplantation may in part acccount for coagulopathies and fibrin deposition during kidney rejection.

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