Radiation-induced sarcoma of head and neck: 50 years of experience at a single institution in an endemic area of nasopharyngeal carcinoma in China

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Ying Xie ◽  
Jian Xu ◽  
Yuan Luo ◽  
Falong Chen ◽  
...  
2000 ◽  
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Hideo Yamane

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Chuan-miao Xie ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
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Sng JHT ◽  
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Lum JL ◽  
Loy CHR ◽  
Yeo JF ◽  
...  

This paper shares a diagnostically challenging case of radiation-induced sarcoma that first presented as gingival ulcerations and pain in a postradiated nasopharyngeal carcinoma patient. Insufficient information from the clinical presentation and non-specific findings from initial imaging results hindered early diagnosis. Nonetheless, correlation with medical history, prompt histopathological analysis and PET-CT imaging eventually led to a definitive diagnosis. This case report aims to increase the awareness of this uncommonly known but deadly long-term complication of head and neck radiotherapy. Clinicians ought to include radiation-induced sarcoma in their list of differential diagnosis when a patient, with a history of head and neck radiotherapy, presents with persistent gingival or oral mucosa lesions, alveolar bony exposure or other suspicious dental-related symptoms.


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