Plasma Exchange for Hemolytic Crisis and Acute Liver Failure in Wilson Disease

2013 ◽  
Vol 81 (5) ◽  
pp. 498-500 ◽  
Author(s):  
Nishant Verma ◽  
Gautham Pai ◽  
Pankaj Hari ◽  
Rakesh Lodha
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Wilson Disease ◽  
Hemolytic Crisis

Plasma exchange and chelator therapy rescues acute liver failure in Wilson disease without liver transplantation

2016 ◽  
Vol 47 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Jun Kido ◽  
Shirou Matsumoto ◽  
Ken Momosaki ◽  
Rieko Sakamoto ◽  
Hiroshi Mitsubuchi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Wilson Disease

Reversal of Acute Liver Failure Due to Wilson Disease by a Regimen of High‐Volume Plasma Exchange and Penicillamine

Hepatology ◽  
2019 ◽  
Vol 69 (4) ◽  
pp. 1835-1837 ◽  
Author(s):  
Jakob Damsgaard ◽  
Fin Stolze Larsen ◽  
Henriette Ytting
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Wilson Disease ◽  
High Volume

Plasmapheresis for hemolytic crisis and impending acute liver failure in Wilson disease

2007 ◽  
Vol 22 (5) ◽  
pp. 295-298 ◽  
Author(s):  
Samuel Asfaha ◽  
Mohammed Almansori ◽  
Uwais Qarni ◽  
Klaus S. Gutfreund
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Wilson Disease ◽  
Hemolytic Crisis

Ninety days transplant free survival with high volume plasma exchange in Wilson disease presenting as acute liver failure

2020 ◽  
Author(s):  
Arti Pawaria ◽  
Vikrant Sood ◽  
Bikrant Bihari Lal ◽  
Rajeev Khanna ◽  
Meenu Bajpai ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Wilson Disease ◽  
High Volume ◽  
Free Survival

scholarly journals Wilson Disease-Induced Acute Liver Failure (NWI = 13) Salvaged without Liver Transplant by Plasmapheresis

2021 ◽  
Vol 11 (01) ◽  
pp. e145-e147
Author(s):  
Nida Mirza ◽  
Ravi Bharadwaj ◽  
Smita Malhotra ◽  
Anupam Sibal
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Wilson Disease ◽  
Prognostic Score ◽  
Prognostic Index ◽  
Kidney Injury ◽  
Copper Metabolism ◽  
Life Saving ◽  
The Brain

AbstractWilson disease (WD) is a disorder of copper metabolism resulting in accumulation of copper in vital organs of the human body, predominantly in the liver and the brain. Acute liver failure in WD has a bad prognosis, especially with a score ≥11 in the revised WD prognostic index; emergency liver transplantation is considered the only life-saving option in this scenario. Here, we reported a girl patient with WD-induced liver failure and poor prognostic score who was rescued by plasmapheresis. She also manifested severe Coombs negative hemolytic anemia and acute kidney injury. This case report highlights the utility of an adjunctive modality besides liver transplantation for the management of fulminant liver failure caused by WD.

scholarly journals Reply to: “Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?”

2019 ◽  
Vol 70 (3) ◽  
pp. 566-567 ◽  
Author(s):  
Eleonora De Martin ◽  
Jean-Marie Michot ◽  
Barbara Papouin ◽  
Stephane Champiat ◽  
Olivier Lambotte ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Treatment Strategies ◽  
Immune Mediated ◽  
New Treatment

scholarly journals Therapeutic plasma exchange in children with acute liver failure (ALF): is it time for incorporation into the ALF armamentarium?

2021 ◽  
Author(s):  
Emma C. Alexander ◽  
Akash Deep
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Systemic Circulation ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Randomised Controlled ◽  
Liver Assist Devices

AbstractPaediatric acute liver failure (PALF) is a rare but devastating condition with high mortality. An exaggerated inflammatory response is now recognised as pivotal in the pathogenesis and prognosis of ALF, with cytokine spill from the liver to systemic circulation implicated in development of multi-organ failure associated with ALF. With advances in medical management, especially critical care, there is an increasing trend towards spontaneous liver regeneration, averting the need for emergency liver transplantation or providing stability to the patient awaiting a graft. Hence, research is ongoing for therapies, including extracorporeal liver support devices, that can bridge patients to transplant or spontaneous liver recovery. Considering the immune-related pathogenesis and inflammatory phenotype of ALF, plasma exchange serves as an ideal liver assist device as it performs both the excretory and synthetic functions of the liver and, in addition, works as an immunomodulatory therapy by suppressing the early innate immune response in ALF. After a recent randomised controlled trial in adults demonstrated a beneficial effect of high-volume plasma exchange on clinical outcomes, this therapy was incorporated in European Association for the Study of Liver (EASL) recommendations for managing adult patients with ALF, but no guidelines exist for PALF. In this review, we discuss rationale, timing, practicalities, and existing evidence regarding the use of plasma exchange as an immunomodulatory treatment in PALF. We discuss controversies in delivery of this therapy as an extracorporeal device, and practicalities of use of plasma exchange as a ‘hybrid’ therapy alongside other extracorporeal liver assist devices, before finally reviewing outstanding research questions for the future.

High volume plasma exchange in acute liver failure: Dampening the inflammatory cascade?

2016 ◽  
Vol 64 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Constantine J. Karvellas ◽  
R. Todd Stravitz
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume ◽  
Inflammatory Cascade
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