scholarly journals Genetic Polymorphisms in the Vitamin D Pathway and Non-small Cell Lung Cancer Survival

2019 ◽  
Vol 26 (3) ◽  
pp. 1709-1715 ◽  
Author(s):  
Jinyu Kong ◽  
Xiaojie Chen ◽  
Jian Wang ◽  
Jingxin Li ◽  
Fangxiu Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Cancer Survival ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Nucleotide Polymorphisms ◽  
Small Cell Lung

Abstract Various genetic polymorphisms have been linked to lung cancer susceptibility and survival outcomes. Vitamin D (VD) regulates cell proliferation and differentiation, inhibits tumor growth and induces apoptosis. Observations from several previous studies including our own suggest that genetic polymorphisms in the VD pathway may be associated with lung cancer risk. The aim of this study is to assess if genetic polymorphisms in the VD pathway are associated with the prognosis of non-small cell lung cancer (NSCLC). Nine single nucleotide polymorphisms (SNPs) in five genes in the VD pathway were genotyped with the TaqMan assays in 542 patients with primary NSCLC, and the relationships between these SNPs and overall survival were evaluated. We found that SNP rs10741657 in the CYP2R1 gene was associated with the prognosis of NSCLC, especially in elderly patients and not being treated with chemotherapy. Some of the VD pathway-related genetic polymorphisms may influence the prognosis of NSCLC. More research is needed to further confirm the finding and test if VD supplements can be used for NSCLC treatment.

scholarly journals Association of the vitamin D metabolism gene GC and CYP27B1 polymorphisms with cancer susceptibility: a meta-analysis and trial sequential analysis

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Man Zhu ◽  
Zheqiong Tan ◽  
Zhenzhao Luo ◽  
Hui Hu ◽  
Tangwei Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Cancer Type ◽  
Small Cell Lung ◽  
Cancer Risks

Abstract Nowadays, vitamin D is known to have functions beyond bone formation, including inhibiting angiogenesis and promoting tumor apoptosis. CYP27B1 and group-specific component (GC), the main enzyme responsible for the degradation and transport of active vitamin D, play important role in many cancer-related cellular processes. Relationships between CYP27B1 and GC polymorphisms and cancer susceptibility have been widely investigated, whereas the results are inconsistent. We strictly searched EMBASE, PubMed, Web of Science, WanFang and CNKI electronic databases for relevant studies exploring the associations of GC (rs4588 and rs7041) and CYP27B1 (rs4646537, rs3782130) polymorphisms with cancer risks according to search strategy. Thirty-two studies published in 13 articles involving 15713 cases and 17304 controls were included. Our analyses suggested that rs4588 and rs7041 polymorphisms were significantly associated with overall cancer risk. Stratification analyses of ethnicity indicated that rs4588 polymorphism significantly increased cancer risk in Caucasians and Asians, while rs7041 polymorphism significantly increased cancer risk in Asians. When studies were stratified by cancer type, our results indicated that rs4588 significantly increased the risk of breast cancer and digestive system tumor, but not in prostate cancer and non-small cell lung cancer, while rs7041 significantly increased the risk of non-small cell lung cancer. Above associations were noteworthy findings as evaluated by false-positive report probabilities (FPRPs). There were no associations of rs4646537 and rs3782130 with overall cancer risks. Associations between CYP27B1 and GC polymorphisms and cancer risks were examined, and additional large samples are necessary to validate our results.

scholarly journals Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response

2014 ◽  
Vol 12 (4) ◽  
pp. 550-559 ◽  
Author(s):  
Timothy G. Whitsett ◽  
Ian T. Mathews ◽  
Michael H. Cardone ◽  
Ryan J. Lena ◽  
William E. Pierceall ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Therapeutic Response ◽  
Cancer Survival ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Survival

Genetic polymorphisms and treatment response in advanced non-small cell lung cancer

Lung Cancer ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 281-288 ◽  
Author(s):  
Dan Su ◽  
Shenglin Ma ◽  
Peng Liu ◽  
Zhiming Jiang ◽  
Wangxia Lv ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Treatment Response ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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