Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer

2019 ◽  
Vol 13 (3) ◽  
pp. 349-356 ◽  
Author(s):  
Aarti Asnani ◽  
Xu Shi ◽  
Laurie Farrell ◽  
Rahul Lall ◽  
Igal A. Sebag ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Citric Acid ◽  
Citric Acid Cycle ◽  
Anthracycline Cardiotoxicity ◽  
Acid Cycle ◽  
Nucleoside Metabolism

scholarly journals Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

2012 ◽  
Vol 444 (3) ◽  
pp. 561-571 ◽  
Author(s):  
Anne R. Diers ◽  
Katarzyna A. Broniowska ◽  
Ching-Fang Chang ◽  
Neil Hogg
Keyword(s):  
Breast Cancer ◽  
Citric Acid ◽  
Cancer Cells ◽  
Mitochondrial Function ◽  
Mitochondrial Respiration ◽  
Breast Cancer Cells ◽  
Citric Acid Cycle ◽  
Metabolic Reprogramming ◽  
Metabolic Phenotype ◽  
Acid Cycle

Recent studies have highlighted the fact that cancer cells have an altered metabolic phenotype, and this metabolic reprogramming is required to drive the biosynthesis pathways necessary for rapid replication and proliferation. Specifically, the importance of citric acid cycle-generated intermediates in the regulation of cancer cell proliferation has been recently appreciated. One function of MCTs (monocarboxylate transporters) is to transport the citric acid cycle substrate pyruvate across the plasma membrane and into mitochondria, and inhibition of MCTs has been proposed as a therapeutic strategy to target metabolic pathways in cancer. In the present paper, we examined the effect of different metabolic substrates (glucose and pyruvate) on mitochondrial function and proliferation in breast cancer cells. We demonstrated that cancer cells proliferate more rapidly in the presence of exogenous pyruvate when compared with lactate. Pyruvate supplementation fuelled mitochondrial oxygen consumption and the reserve respiratory capacity, and this increase in mitochondrial function correlated with proliferative potential. In addition, inhibition of cellular pyruvate uptake using the MCT inhibitor α-cyano-4-hydroxycinnamic acid impaired mitochondrial respiration and decreased cell growth. These data demonstrate the importance of mitochondrial metabolism in proliferative responses and highlight a novel mechanism of action for MCT inhibitors through suppression of pyruvate-fuelled mitochondrial respiration.

EFFECT OF SERUM GONADOTROPHIN ON DEHYDROGENASES OF THE CITRIC ACID CYCLE IN THE OVARY OF THE RAT

1963 ◽  
Vol 42 (4) ◽  
pp. 480-484 ◽  
Author(s):  
B. Eckstein ◽  
R. Landsberg
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Age Groups ◽  
Succinic Dehydrogenase ◽  
Immature Rat ◽  
Acid Cycle ◽  
Immature Rats ◽  
Rat Ovary

ABSTRACT The succinic, malic and isocitric dehydrogenases in the ovary of immature and mature, normal and serum gonadotrophin injected rats were examined. The Qo2 of these enzymes were markedly enhanced in the gonadotrophin injected rats of both age groups, except in the case of succinic dehydrogenase in the ovary of the immature rats, where a slight non-significant decrease was noted. It is concluded that in the mature rat ovary, gonadotrophin administration stimulates the activity of all the examined dehydrogenases of the citric acid cycle, whereas in the immature rat ovary, at least the isocitric- and malic dehydrogenases are thus stimulated.

scholarly journals CHROMATOGRAPHIC DETERMINATION OF THE ACIDS OF THE CITRIC ACID CYCLE IN TISSUES

1951 ◽  
Vol 193 (1) ◽  
pp. 277-283 ◽  
Author(s):  
CharlesE. Frohman ◽  
JamesM. Orten ◽  
ArthurH. Smith
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Chromatographic Determination ◽  
Acid Cycle

Clustering of sequential enzymes in the glycolytic pathway and the citric acid cycle

1990 ◽  
Vol 43 (4) ◽  
pp. 297-306 ◽  
Author(s):  
Sonia Beeckmans ◽  
Edilbert Van Driessche ◽  
Louis Kanarek
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Glycolytic Pathway ◽  
Acid Cycle
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