Double Cisterna Magna Blood Injection Model of Experimental Subarachnoid Hemorrhage in Dogs

2014 ◽  
Vol 5 (6) ◽  
pp. 647-652 ◽  
Author(s):  
Kentaro Mori
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cisterna Magna ◽  
Injection Model ◽  
Experimental Subarachnoid Hemorrhage ◽  
Blood Injection

Abstract T P242: Cognitive Dysfunction in a Pre-chiasmatic Cistern Blood Injection Model of Aneurysmal Subarachnoid Hemorrhage In Mice

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Fumiaki Oka ◽  
Yahya B Atalay ◽  
Tao Qin ◽  
Cenk Ayata
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cognitive Dysfunction ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Laser Speckle ◽  
Cisterna Magna ◽  
Arterial Blood ◽  
Y Maze ◽  
Injection Model ◽  
Blood Injection ◽  
Underlying Mechanisms

Background: Majority of aneurysmal subarachnoid hemorrhage (SAH) survivors develop cognitive dysfunction. To better understand the underlying mechanisms and develop treatments, predictive animal models are required. We carried out a detailed physiological and cognitive characterization of pre-chiasmatic cistern (PC) and cisterna magna (CM) SAH models in mice. Methods: SAH was induced by arterial blood injection into the PC (40 μl) or CM (60 μl) in C57BL6/J mice (male, 25g). Controls received normal saline. Cerebral blood flow (CBF) was imaged using laser speckle flowmetry during and for 60 min after SAH. Intracranial pressure (ICP) and blood pressure (BP) were monitored to calculate cerebral perfusion pressure (CPP). Neurological and cognitive function was assessed 3 weeks after the injection, using pole, novel object recognition, Y maze and Morris water maze tests. Results: Mortality was 10% after PC and 4% after CM SAH. In both groups, CPP decreased from about 65 mmHg to less than 10 mmHg immediately after the injection, and recovered to 40 mmHg within 10 min after PC (n=8) and 7 min after CM (n=8) SAH (Fig A). In both groups, CBF was severely reduced to ~20% of baseline in both hemispheres immediately after SAH. CBF recovered to >40% within 5 min after PC and 2 min after CM SAH (Fig A). In saline controls (n=5 in PC and CM each), CPP and CBF changes were much milder and shorter-lasting. Compared with controls (n=12), PC SAH mice (n=12) performed significantly worse in a subset of sensorimotor and cognitive tests for up to 3 weeks (Fig B). CM SAH did not significantly impact neurological function. Conclusions: Pre-chiasmatic cistern but not cisterna magna SAH model reproduces cognitive dysfunction observed in patients with low mortality and high reproducibility in mice.

Effect of Graded Hyperventilation on Cerebral Metabolism in a Cisterna Magna Blood Injection Model of Subarachnoid Hemorrhage in Rats

2006 ◽  
Vol 18 (1) ◽  
pp. 18-23 ◽  
Author(s):  
XiaoDong Ma ◽  
Rikke Bay-Hansen ◽  
John Hauerberg ◽  
Gitte Moos Knudsen ◽  
Niels Vidiendal Olsen ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Metabolism ◽  
Cisterna Magna ◽  
Injection Model ◽  
Blood Injection

scholarly journals A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats

2012 ◽  
Vol 4 (1) ◽  
Author(s):  
Furat Raslan ◽  
Christiane Albert-Weißenberger ◽  
Thomas Westermaier ◽  
Saker Saker ◽  
Christoph Kleinschnitz ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Cisterna Magna ◽  
Double Injection ◽  
Delayed Cerebral Vasospasm ◽  
Injection Model

Negative Allosteric Modulator of mGluR1 Improves Long-Term Neurologic Deficits after Experimental Subarachnoid Hemorrhage

2020 ◽  
Vol 11 (18) ◽  
pp. 2869-2880
Author(s):  
Hong-Bin Wang ◽  
Wei-qi Wang ◽  
Qing-Jian Wu ◽  
Ya-jun Hou ◽  
Han-xia Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Allosteric Modulator ◽  
Neurologic Deficits ◽  
Experimental Subarachnoid Hemorrhage ◽  
Negative Allosteric Modulator

scholarly journals Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

2019 ◽  
Vol 152 (3) ◽  
pp. 368-380 ◽  
Author(s):  
Yuke Xie ◽  
Jianhua Peng ◽  
Jinwei Pang ◽  
Kecheng Guo ◽  
Lifang Zhang ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Microglial Activation ◽  
Early Brain Injury ◽  
Experimental Subarachnoid Hemorrhage
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