Preparation and characterization of calcium phosphate cement of α-tricalcium phosphate-tetracalcium phosphate-dicalcium phosphate system incorporated with poly(γ-glutamic acid)

Titration curves of calcium-containing and calcium-free solutions resembling milk serum indicated that precipitation of calcium from such solutions was greatly impeded by citrate. In the absence of citrate, precipitation of tricalcium phosphate was complete at pH 6·0, but, in solutions containing citrate, precipitation of tricalcium phosphate occurred gradually throughout the titration and was not complete at pH 10.In some solutions precipitation of calcium phosphate ceased at about pH 9·7, even though the base added had been insufficient to neutralize tertiary hydrogen equivalent to the known calcium content. Precipitation of dicalcium phosphate must therefore have occurred.The observed stability of calcium in these solutions was much greater than that predicted from the accepted solubility and dissociation constants. It is therefore concluded that detailed studies of these constants, and of the factors controlling precipitation of dior tricalcium phosphate, are needed.

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Preparation and characterization of calcium phosphate cement with enhanced tissue adhesion for bone defect repair

Ceramics International ◽

10.1016/j.ceramint.2020.08.288 ◽

2021 ◽

Vol 47 (2) ◽

pp. 1712-1720

Author(s):

Weibin Zhong ◽

Lin Sun ◽

Tao Yu ◽

Changren Zhou

Keyword(s):

Calcium Phosphate ◽

Bone Defect ◽

Calcium Phosphate Cement ◽

Tissue Adhesion ◽

Bone Defect Repair ◽

Defect Repair

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Polymeric-Calcium Phosphate Cement Composites-Material Properties:In VitroandIn VivoInvestigations

International Journal of Biomaterials ◽

10.1155/2010/691452 ◽

2010 ◽

Vol 2010 ◽

pp. 1-14 ◽

Cited By ~ 16

Author(s):

Rania M. Khashaba ◽

Mervet M. Moussa ◽

Donald J. Mettenburg ◽

Frederick A. Rueggeberg ◽

Norman B. Chutkan ◽

...

Keyword(s):

Calcium Phosphate ◽

Calcium Phosphate Cement ◽

Setting Time ◽

Cement Composites ◽

Tetracalcium Phosphate ◽

Methyl Vinyl Ether ◽

Orthopedic Applications ◽

Hydroxyapatite Cement

New polymeric calcium phosphate cement composites (CPCs) were developed. Cement powder consisting of 60 wt% tetracalcium phosphate, 30 wt% dicalcium phosphate dihydrate, and 10 wt% tricalcium phosphate was combined with either 35% w/w poly methyl vinyl ether maleic acid or polyacrylic acid to obtain CPC-1 and CPC-2. The setting time and compressive and diametral tensile strength of the CPCs were evaluated and compared with that of a commercial hydroxyapatite cement.In vitrocytotoxicity andin vivobiocompatibility of the two CPCs and hydroxyapatite cement were assessed. The setting time of the cements was 5–15 min. CPC-1 and CPC-2 showed significantly higher compressive and diametral strength values compared to hydroxyapatite cement. CPC-1 and CPC-2 were equivalent to Teflon controls after 1 week. CPC-1, CPC-2, and hydroxyapatite cement elicited a moderate to intense inflammatory reaction at 7 days which decreased over time. CPC-1 and CPC-2 show promise for orthopedic applications.

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