Metabolic flux analysis on succinic acid production from crude glycerol by Actinobacillus succinogenes

2021 ◽  
Author(s):  
Omjit Sillaparassamee ◽  
Sopa Chinwetkitvanich ◽  
Suwimon Kanchanasuta ◽  
Nipon Pisutpaisal ◽  
Verawat Champreda
Keyword(s):  
Succinic Acid ◽  
Metabolic Flux Analysis ◽  
Acid Production ◽  
Crude Glycerol ◽  
Metabolic Flux ◽  
Flux Analysis ◽  
Actinobacillus Succinogenes ◽  
Succinic Acid Production

scholarly journals Optimization of bio-succinic fermentation process from crude glycerol by Actinobacillus succinogenes

2020 ◽  
Vol 26 (4) ◽  
pp. 200121-0
Author(s):  
Suwimon Kanchanasuta ◽  
Verawat Champreda ◽  
Nipon Pisutpaisal ◽  
Chatchawal Singhakant
Keyword(s):  
Acetic Acid ◽  
Succinic Acid ◽  
Acid Concentration ◽  
Acid Production ◽  
Crude Glycerol ◽  
Fermentation Process ◽  
Utilization Efficiency ◽  
Actinobacillus Succinogenes ◽  
Fed Batch ◽  
Succinic Acid Production

Bio-succinic acid is a commodity chemical with potent application in bioplastic and food industries which can be produced from renewable resources. In this study, bioprocess for production of bio-succinic from glycerol by Actinobacillus succinogenes was studied. The maximum succinic acid concentration in small-scale serum bottle experiments was 6.8 and 6.5 g/L using pure and crude glycerol, respectively, with supplemented MgCO3. The ratio of acetic acid to succinic acid (AA/SA) implied the increased carbon flux to the C4 pathway using crude glycerol supplemented with MgCO3 compared to that with CaCO3.The carbonate salts tended to induce C3 metabolic pathway in fermentation using pure glycerol which was in accordance with the ratio of acetic acid to glycerol (AA/GL). The highest succinic acid concentration of 17.9 g/L from crude glycerol was achieved from batch fermentation in a lab-scale fermenter with the maximum glycerol utilization of 99.9% which were higher than those obtained from fed- batch and semi-continuous processes. Acetic acid tended to increase throughout the fermentation process in fed-batch and semi-continuous operations, which resulted in the lower product yield and substrate utilization efficiency. The time for initial purging of CO2 showed effects on succinic acid production and internal metabolic pathways. This work provided a basis for process development on bio-succinic acid production from crude glycerol in industry.

Opportunities, challenges, and future perspectives of succinic acid production by Actinobacillus succinogenes

2018 ◽  
Vol 102 (23) ◽  
pp. 9893-9910 ◽  
Author(s):  
Wubliker Dessie ◽  
Fengxue Xin ◽  
Wenming Zhang ◽  
Youming Jiang ◽  
Hao Wu ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Acid Production ◽  
Actinobacillus Succinogenes ◽  
Future Perspectives ◽  
Succinic Acid Production

Succinic acid production from duckweed (Landoltia punctata) hydrolysate by batch fermentation of Actinobacillus succinogenes GXAS137

2016 ◽  
Vol 211 ◽  
pp. 307-312 ◽  
Author(s):  
Naikun Shen ◽  
Qingyan Wang ◽  
Jing Zhu ◽  
Yan Qin ◽  
Siming Liao ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Acid Production ◽  
Batch Fermentation ◽  
Actinobacillus Succinogenes ◽  
Succinic Acid Production

Succinic acid production by Actinobacillus succinogenes using hydrolysates of spent yeast cells and corn fiber

2011 ◽  
Vol 102 (2) ◽  
pp. 1704-1708 ◽  
Author(s):  
Ke-Quan Chen ◽  
Jian Li ◽  
Jiang-Feng Ma ◽  
Min Jiang ◽  
Ping Wei ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Acid Production ◽  
Corn Fiber ◽  
Yeast Cells ◽  
Actinobacillus Succinogenes ◽  
Succinic Acid Production

Low cost nutrient-rich oil palm trunk bagasse hydrolysate for bio-succinic acid production by Actinobacillus succinogenes

2021 ◽  
pp. 1-11
Author(s):  
Nurul Adela Bukhari ◽  
Soh Kheang Loh ◽  
Abdullah Amru Indera Luthfi ◽  
Peer Mohamed Abdul ◽  
Jamaliah Md Jahim
Keyword(s):  
Succinic Acid ◽  
Oil Palm ◽  
Acid Production ◽  
Low Cost ◽  
Actinobacillus Succinogenes ◽  
Oil Palm Trunk ◽  
Succinic Acid Production
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