scholarly journals Temporal Trends and Outcomes of Elective Thoracic Aortic Repair and Acute Aortic Syndromes in Bicuspid Aortic Valves: Insights from a National Database

2021 ◽  
Author(s):  
Ayman Elbadawi ◽  
Ahmad A. Mahmoud ◽  
Karim Mahmoud ◽  
Islam Y. Elgendy ◽  
Mohmed A. Omer ◽  
...  
Keyword(s):  
Temporal Trends ◽  
National Database ◽  
Aortic Valves ◽  
Aortic Repair ◽  
Acute Aortic Syndromes ◽  
Bicuspid Aortic Valves

scholarly journals TEMPORAL TRENDS AND OUTCOMES OF ELECTIVE AORTIC REPAIR AND ACUTE AORTIC SYNDROMES IN PATIENTS WITH BICUSPID AORTIC VALVES

2020 ◽  
Vol 75 (11) ◽  
pp. 2223
Author(s):  
Ayman Elbadawi ◽  
Ahmad Mahmoud ◽  
Islam Elgendy ◽  
Mohamed Omer ◽  
Gbolahan Ogunbayo ◽  
...  
Keyword(s):  
Temporal Trends ◽  
Aortic Valves ◽  
Aortic Repair ◽  
Acute Aortic Syndromes ◽  
Bicuspid Aortic Valves

scholarly journals Simplified determination of commissural orientation in bicuspid aortic valves

2020 ◽  
Vol 58 (6) ◽  
pp. 1153-1160
Author(s):  
Lennart Froede ◽  
Sebastian Schäfers ◽  
Gudrun Wagenpfeil ◽  
Alexander Raddatz ◽  
Klaus Hoffmann ◽  
...  
Keyword(s):  
Decision Making ◽  
Line Segment ◽  
Aortic Valves ◽  
Methods Of Determination ◽  
Geometric Methods ◽  
Aortic Repair ◽  
Bicuspid Aortic Valves

Abstract OBJECTIVES In bicuspid aortic valves (BAV), commissural orientation (CO) varies between 180° and close to 120°. Postoperative CO has a strong effect on repair durability, and different repair approaches have been proposed according to CO; it is thus important for aortic repair. A precise, simple and reproducible determination by preoperative echocardiography would facilitate intraoperative decision-making. We compared 4 different methods of determination of CO in BAV. METHODS Preoperative transoesophageal echocardiograms of 62 patients with BAV were analysed. CO was measured using either the coaptation centre or the geometric centre of the root. The geometric centre of the root was determined through approximation using a circle or an ellipse, or the midpoint of a line between the centre of the non-fused and the fused sinuses. RESULTS The 3 different geometric methods led to almost identical results (interclass coefficient 0.98–0.99), with the line segment being the easiest to use. The use of the coaptation centre was associated with the underestimation of commissural angle of up to 30° compared to the geometric centre; the discrepancy was significant and most pronounced for asymmetric BAV (140–160°; P = 0.005). CONCLUSIONS CO can reproducibly be determined using a line segment between the centre of the non-fused and fused sinuses. The use of the coaptation centre can lead to misleading results, in particular in asymmetric BAVs.

Pericardial patch augmentation for incompetant bicuspid aortic valves at longterm

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
M Doss ◽  
M Thudt ◽  
A Miskovic ◽  
A Moritz
Keyword(s):  
Pericardial Patch ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

2015 ◽  
Vol 18 (4) ◽  
pp. 134 ◽  
Author(s):  
Asad A Shah
Keyword(s):  
Gene Expression ◽  
Aortic Aneurysm ◽  
Methylation Status ◽  
Aortic Aneurysms ◽  
Aortic Valves ◽  
Ascending Aortic Aneurysm ◽  
Novel Genes ◽  
Aneurysm Formation ◽  
Aortic Replacement ◽  
Bicuspid Aortic Valves

<p><strong>Background:  </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods:  </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.  Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.  Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.  </p><p><strong>Results:  </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>).  The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients.  Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range:  -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions:  </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms.  The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders.  These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>

Proximal Aortic Repair in Dialysis Patients: A National Database Analysis

2021 ◽  
Author(s):  
Takuya Ogami ◽  
Eric Zimmermann ◽  
Roger Zhu ◽  
Yanling Zhao ◽  
Yuming Ning ◽  
...  
Keyword(s):  
National Database ◽  
Dialysis Patients ◽  
Database Analysis ◽  
Aortic Repair

Serial echocardiography for valve dysfunction and aortic dilation in bicuspid aortic valves

2021 ◽  
Vol 38 (3) ◽  
pp. 394-401
Author(s):  
Matthew W. Parker ◽  
Renee Dallasen Muchnik ◽  
Adedotun Ogunsua ◽  
Amartya Kundu ◽  
Suvasini Lakshmanan ◽  
...  
Keyword(s):  
Aortic Dilation ◽  
Aortic Valves ◽  
Valve Dysfunction ◽  
Bicuspid Aortic Valves
Sign in / Sign up

Export Citation Format

Share Document