Serial echocardiography for valve dysfunction and aortic dilation in bicuspid aortic valves

2021 ◽  
Vol 38 (3) ◽  
pp. 394-401
Author(s):  
Matthew W. Parker ◽  
Renee Dallasen Muchnik ◽  
Adedotun Ogunsua ◽  
Amartya Kundu ◽  
Suvasini Lakshmanan ◽  
...  
Keyword(s):  
Aortic Dilation ◽  
Aortic Valves ◽  
Valve Dysfunction ◽  
Bicuspid Aortic Valves

Relation of Coarctation of the Aorta to the Occurrence of Ascending Aortic Dilation in Children and Young Adults With Bicuspid Aortic Valves

2009 ◽  
Vol 103 (2) ◽  
pp. 266-270 ◽  
Author(s):  
Andrea Z. Beaton ◽  
Thieu Nguyen ◽  
Wyman W. Lai ◽  
Samprit Chatterjee ◽  
Prema Ramaswamy ◽  
...  
Keyword(s):  
Young Adults ◽  
Coarctation Of The Aorta ◽  
Aortic Dilation ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves ◽  
Children And Young Adults

scholarly journals Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves

1992 ◽  
Vol 19 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Rebecca T. Hahn ◽  
Mary J. Roman ◽  
Allen H. Mogtadek ◽  
Richard B. Devereux
Keyword(s):  
Aortic Dilation ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves

Pericardial patch augmentation for incompetant bicuspid aortic valves at longterm

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
M Doss ◽  
M Thudt ◽  
A Miskovic ◽  
A Moritz
Keyword(s):  
Pericardial Patch ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

2015 ◽  
Vol 18 (4) ◽  
pp. 134 ◽  
Author(s):  
Asad A Shah
Keyword(s):  
Gene Expression ◽  
Aortic Aneurysm ◽  
Methylation Status ◽  
Aortic Aneurysms ◽  
Aortic Valves ◽  
Ascending Aortic Aneurysm ◽  
Novel Genes ◽  
Aneurysm Formation ◽  
Aortic Replacement ◽  
Bicuspid Aortic Valves

<p><strong>Background:  </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods:  </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.  Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.  Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.  </p><p><strong>Results:  </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>).  The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients.  Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range:  -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions:  </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms.  The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders.  These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>

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