Chiral Phase-transfer Catalysts Bearing Multiple Hydrogen-bonding Donors Derived from Amino Acids: Efficient Catalysts for Diastereo- and Enantioselective Nitro-Mannich Reaction

2018 ◽  
Vol 34 (3) ◽  
pp. 333-337
Author(s):  
Yu Liu ◽  
Zhonglin Wei ◽  
Yuxin Liu ◽  
Jingdong Wang ◽  
Jungang Cao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hydrogen Bonding ◽  
Mannich Reaction ◽  
Phase Transfer ◽  
Chiral Phase ◽  
Phase Transfer Catalysts ◽  
Chiral Phase Transfer Catalysts ◽  
Multiple Hydrogen Bonding

Diastereo- and enantioselective nitro-Mannich reaction of isatin-derived N-Boc ketimines catalyzed by chiral phase-transfer catalysts

2018 ◽  
Vol 42 (3) ◽  
pp. 1608-1611 ◽  
Author(s):  
Yuxin Liu ◽  
Jingdong Wang ◽  
Zhonglin Wei ◽  
Jungang Cao ◽  
Dapeng Liang ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Phase Transfer ◽  
Cinchona Alkaloid ◽  
Chiral Phase ◽  
Phase Transfer Catalysts ◽  
Chiral Phase Transfer Catalysts

A series of 3-substituted 3-amino-oxindoles were constructed in excellent yields (96–99%) with high enantioselectivities (up to 95% ee) and diastereoselectivities (up to 95 : 5 dr) catalyzed by Cinchona alkaloid-derived phase-transfer catalysts.

Sign in / Sign up

Export Citation Format

Share Document