A set of δ-amino γ-butenolides (1-5) were synthesised by a novel method using molecular iodine as a catalyst by mannich reaction. The purity and progress of the reaction was assessed by thin layer chromatography and the compounds characterisation was done by IR, proton NMR and mass spectroscopic techniques. Molecular modeling studies for the compounds such as docking was performed for the synthesized butenolides to understand the drug receptor interactions and analyze structural changes when bound to the active site of the receptor. the results showed that the compounds 2 and 3 showed significant interaction with target enzymes.
Sustainable tannin-based coagulants synthesized through Mannich reaction using melamine as an amine source for water treatment applications
