scholarly journals Pharmacokinetics of DFN-15, a Novel Oral Solution of Celecoxib, Versus Celecoxib 400-mg Capsules: A Randomized Crossover Study in Fasting Healthy Volunteers

2017 ◽  
Vol 37 (10) ◽  
pp. 937-946 ◽  
Author(s):  
Arindam Pal ◽  
Srinivas Shenoy ◽  
Anirudh Gautam ◽  
Sagar Munjal ◽  
Jing Niu ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Oral Solution ◽  
Randomized Crossover Study

Pharmacokinetics and Safety of Coadministered Oseltamivir and Rimantadine in Healthy Volunteers: An Open-Label, Multiple-Dose, Randomized, Crossover Study

2012 ◽  
Vol 52 (8) ◽  
pp. 1255-1264 ◽  
Author(s):  
Georgina Cirrincione-Dall ◽  
Barbara J. Brennan ◽  
Rosa M. Ballester-Sanchis ◽  
Mercidita T. Navarro ◽  
Brian E. Davies
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Multiple Dose ◽  
Open Label ◽  
Randomized Crossover Study

scholarly journals Enhanced Bioavailability of Itraconazole in Hydroxypropylβ-Cyclodextrin Solution versus Capsules in Healthy Volunteers

1998 ◽  
Vol 42 (7) ◽  
pp. 1862-1865 ◽  
Author(s):  
Joseph A. Barone ◽  
Bruce L. Moskovitz ◽  
Joseph Guarnieri ◽  
Alan E. Hassell ◽  
John L. Colaizzi ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Oral Solution ◽  
Solution Versus ◽  
Male Volunteers ◽  
The Times

ABSTRACT The bioavailabilities and bioequivalences of single 200-mg doses of itraconazole solution and two capsule formulations were evaluated in a crossover study of 30 male volunteers. The two capsule formulations were bioequivalent. The bioavailabilities of the solutions itraconazole and hydroxyitraconazole were 30 to 33% and 35 to 37% greater, respectively, than those of either capsule. However, the maximum concentrations of the drug in plasma (C max), the times to C max, and the terminal half-lives were comparable for all three formulations. These data indicate that the bioavailabilities of itraconazole and hydroxyitraconazole are enhanced when administered as an oral solution instead of capsules.

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