Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan

P. N. Sidharta; A. Treiber; J. Dingemanse

doi:10.1007/s40262-015-0255-5

Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan

Clinical Pharmacokinetics ◽

10.1007/s40262-015-0255-5 ◽

2015 ◽

Vol 54 (5) ◽

pp. 457-471 ◽

Cited By ~ 21

Author(s):

P. N. Sidharta ◽

A. Treiber ◽

J. Dingemanse

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Clinical Pharmacokinetics

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Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2002.01158.x ◽

2002 ◽

Vol 53 (4) ◽

pp. 355-362 ◽

Cited By ~ 26

Author(s):

Jasper Dingemanse ◽

Martine Clozel ◽

Paul L. M. Van Giersbergen

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Chronic Infusion

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Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects

Clinical Pharmacology & Therapeutics ◽

10.1016/s0009-9236(96)90127-7 ◽

1996 ◽

Vol 60 (2) ◽

pp. 124-137 ◽

Cited By ~ 158

Author(s):

Cornelia Weber ◽

Rita Schmitt ◽

Herbert Birnboeck ◽

Gerard Hopfgartner ◽

Sjoerd P. van Marle ◽

...

Keyword(s):

Receptor Antagonist ◽

Human Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Healthy Human ◽

Healthy Human Subjects

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects

The Journal of Clinical Pharmacology ◽

10.1002/jcph.152 ◽

2013 ◽

pp. n/a-n/a ◽

Cited By ~ 15

Author(s):

Patricia N. Sidharta ◽

Paul L. M. van Giersbergen ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Multiple Dose ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Multiple Dose Study ◽

Dose Study

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Effect of the Endothelin-Receptor Antagonist Bosentan on the Pharmacokinetics and Pharmacodynamics of Warfarin

The Journal of Clinical Pharmacology ◽

10.1177/00912709922008380 ◽

1999 ◽

Vol 39 (8) ◽

pp. 847-854 ◽

Cited By ~ 57

Author(s):

Cornelia Weber ◽

Ludger Banken ◽

Herbert Birnboeck ◽

Rainer Schulz

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics

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Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

Drug Design Development and Therapy ◽

10.2147/dddt.s199051 ◽

2019 ◽

Vol Volume 13 ◽

pp. 949-964 ◽

Cited By ~ 9

Author(s):

Patricia Sidharta ◽

Meggane Melchior ◽

Martin K. Kankam ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Multiple Dose ◽

Healthy Adult ◽

Endothelin Receptor Antagonist ◽

Elderly Subjects ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics

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Tolerability, pharmacokinetics, and pharmacodynamics of clazosentan, a parenteral endothelin receptor antagonist

European Journal of Clinical Pharmacology ◽

10.1007/s00228-006-0117-z ◽

2006 ◽

Vol 63 (2) ◽

pp. 151-158 ◽

Cited By ~ 19

Author(s):

Paul L. M. van Giersbergen ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics

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Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of Macitentan, a New Endothelin Receptor Antagonist, in Healthy Japanese Male Subjects

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ◽

10.3999/jscpt.47.143 ◽

2016 ◽

Vol 47 (4) ◽

pp. 143-150 ◽

Cited By ~ 1

Author(s):

Yoshinari YOKOYAMA ◽

Jasper DINGEMANSE ◽

Motonori HATTA ◽

Hiroyuki FUKASE

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Japanese Male ◽

Japanese Male Subjects ◽

Male Subjects

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Pharmacokinetics and Pharmacodynamics of the ETA-Selective Endothelin Receptor Antagonist SPP301 in Healthy Human Subjects

The Journal of Clinical Pharmacology ◽

10.1177/0091270003261047 ◽

2004 ◽

Vol 44 (1) ◽

pp. 59-66 ◽

Cited By ~ 11

Author(s):

Walter Dieterle ◽

Jessica Mann ◽

Klaus Kutz

Keyword(s):

Receptor Antagonist ◽

Human Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Healthy Human ◽

Healthy Human Subjects

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Pharmacokinetics and pharmacodynamics of SB 209670, an endothelin receptor antagonist: Effects on the regulation of renal vascular tone

Clinical Pharmacology & Therapeutics ◽

10.1016/s0009-9236(99)70066-4 ◽

1999 ◽

Vol 65 (5) ◽

pp. 473-482 ◽

Cited By ~ 17

Author(s):

M FREED ◽

D WILSON ◽

K THOMPSON ◽

R HARRIS ◽

B ILSON ◽

...

Keyword(s):

Receptor Antagonist ◽

Vascular Tone ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Renal Vascular ◽

Renal Vascular Tone

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Endothelin Receptor Antagonist

10.32388/54vclc ◽

2020 ◽

Author(s):

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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