scholarly journals Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

2019 ◽  
Vol Volume 13 ◽  
pp. 949-964 ◽  
Author(s):  
Patricia Sidharta ◽  
Meggane Melchior ◽  
Martin K. Kankam ◽  
Jasper Dingemanse
Keyword(s):  
Receptor Antagonist ◽  
Multiple Dose ◽  
Healthy Adult ◽  
Endothelin Receptor Antagonist ◽  
Elderly Subjects ◽  
Endothelin Receptor ◽  
Pharmacokinetics And Pharmacodynamics

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects

1996 ◽  
Vol 60 (2) ◽  
pp. 124-137 ◽  
Author(s):  
Cornelia Weber ◽  
Rita Schmitt ◽  
Herbert Birnboeck ◽  
Gerard Hopfgartner ◽  
Sjoerd P. van Marle ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Human Subjects ◽  
Endothelin Receptor Antagonist ◽  
Endothelin Receptor ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Healthy Human ◽  
Healthy Human Subjects
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