Weighted Lindley multiplicative regression frailty models under random censored data

2021 ◽  
Vol 40 (8) ◽  
Author(s):  
Shikhar Tyagi ◽  
Arvind Pandey ◽  
Varun Agiwal ◽  
Christophe Chesneau
Keyword(s):  
2019 ◽  
Vol 20 (5) ◽  
pp. 502-526
Author(s):  
Shuwei Li ◽  
Tao Hu ◽  
Tiejun Tong ◽  
Jianguo Sun

This article discusses regression analysis of multivariate doubly censored data with a wide class of flexible semiparametric transformation frailty models. The proposed models include many commonly used regression models as special cases such as the proportional hazards and proportional odds frailty models. For inference, we propose a nonparametric maximum likelihood estimation method and develop a new expectation–maximization algorithm for its implementation. The proposed estimators of the finite-dimensional parameters are shown to be consistent, asymptotically normal and semiparametrically efficient. We also conduct a simulation study to assess the finite sample performance of the developed estimation method, and the proposed methodology is applied to a set of real data arising from an AIDS study.


Author(s):  
Arvind Pandey ◽  
David D. Hanagal ◽  
Shikhar Tyagi ◽  
Pragya Gupta

Due to the unavailability of complete data in various circumstances in biological, epidemiological, and medical studies, the analysis of censored data is very common among practitioners. But the analysis of bivariate censored data is not a regular mechanism because it is not necessary to always have independent data. Observed and unobserved covariates affect the variables under study. So, heterogeneity is present in the data. Ignoring observed and unobserved covariates may have objectionable consequences. But it is not easy to find that whether there is any effect of the unobserved covariate or not. Shared frailty models are the viable choice to counter such scenarios. However, due to certain restrictions such as the identifiability condition and the requirement that their Laplace transform exists, finding a frailty distribution can be difficult. As a result, in this paper, we introduce a new frailty distribution generalized Lindley (GL) for reversed hazard rate (RHR) setup that outperforms the gamma frailty distribution. So, our main motive is to establish a new frailty distribution under the RHR setup. By assuming exponential Gumbel (EG) and generalized inverted exponential (GIE) baseline distributions, we propose a new class of shared frailty models based on RHR. We estimate the parameters in these frailty models and use the Bayesian paradigm of the Markov Chain Monte Carlo (MCMC) technique. Model selection criteria have been performed for the comparison of models. We analyze Australian twin data and suggest a better model.


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