Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophic cardiomyopathy

1980 ◽  
Vol 45 (6) ◽  
pp. 1258-1264 ◽  
Author(s):  
Peter Hanrath ◽  
Detlef G. Mathey ◽  
Peter Kremer ◽  
Frank Sonntag ◽  
Walter Bleifeld
Keyword(s):  
Relaxation Time ◽  
Hypertrophic Cardiomyopathy ◽  
Left Ventricular ◽  
Left Ventricular Filling ◽  
Isovolumic Relaxation Time ◽  
Ventricular Filling ◽  
Isovolumic Relaxation

Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling

2017 ◽  
Vol 41 (3) ◽  
pp. 339-343
Author(s):  
Itai Ghersin ◽  
Eduard Ghersin ◽  
Sobhi Abadi ◽  
Jennifer E. Runco Therrien ◽  
Tanyanan Tanawuttiwat ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hypertrophic Cardiomyopathy ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Left Ventricular Filling ◽  
Ventricular Filling

Influence of heart rate on left ventricular isovolumic relaxation time: a Doppler study in healthy newborns

2004 ◽  
Vol 17 (4) ◽  
pp. 330-331 ◽  
Author(s):  
Antonio De Merulis ◽  
Giulio Calcagni ◽  
Paolo Versacci ◽  
Renato Lucchini ◽  
Flavia Ventriglia ◽  
...  
Keyword(s):  
Heart Rate ◽  
Relaxation Time ◽  
Left Ventricular ◽  
Isovolumic Relaxation Time ◽  
Doppler Study ◽  
Isovolumic Relaxation

scholarly journals Doppler Estimation of Left Ventricular Filling Pressures in Patients With Hypertrophic Cardiomyopathy

Circulation ◽  
1999 ◽  
Vol 99 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Sherif F. Nagueh ◽  
Nasser M. Lakkis ◽  
Katherine J. Middleton ◽  
William H. Spencer ◽  
William A. Zoghbi ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Ventricular ◽  
Left Ventricular Filling ◽  
Ventricular Filling

Pulsed Doppler assessment of left ventricular diastolic function in normal and cardiomyopathic cats

1999 ◽  
Vol 35 (4) ◽  
pp. 285-291 ◽  
Author(s):  
JM Bright ◽  
ME Herrtage ◽  
JF Schneider
Keyword(s):  
Relaxation Time ◽  
Diastolic Function ◽  
Peak Velocity ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
P Value ◽  
Pulsed Doppler ◽  
Time Data ◽  
Isovolumic Relaxation Time ◽  
Isovolumic Relaxation

Left ventricular (LV) diastolic function was evaluated in 16 cats with primary hypertrophic cardiomyopathy (HCM) using pulsed Doppler (PD) assessment of transmitral flow and isovolumic relaxation time. Data obtained was compared to data from 12 healthy, adult, research cats. Compared to normal cats, the HCM group showed significantly (p value less than 0.05) reduced early LV inflow velocities (mean +/- standard error [SE], peak velocity of 0.70+/-0.04 m/s versus 0.54+/-0.04 m/s and integrated velocity of 0.48+/-0.08 m/s versus 0.37+/-0.03 m/s); a reduced rate of deceleration of early inflow (mean+/-SE, -12.0+/-1.0 m/s2 versus -5.1+/-1.1 m/s2); prolonged isovolumic relaxation time (mean +/- SE, 45.7+/-3.3 ms versus 76.0+/-3.1 ms); and increased atrial systolic flow velocities (mean +/- SE, peak velocity of 0.29+/-0.04 m/s versus 0.48+/-0.04 m/s and integrated velocity of 0.21+/-0.03 m/s versus 0.34+/-0.03 m/s). The results suggest that PD provides a noninvasive method of identifying and quantifying functional diastolic impairment in cats with HCM.

Brain Natriuretic Peptide: Effect on Left Ventricular Filling Patterns in Healthy Subjects

1995 ◽  
Vol 88 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Peter B. M. Clarkson ◽  
Nigel M. Wheeldon ◽  
Catherine MacLeod ◽  
Wendy Coutie ◽  
Thomas M. MacDonald
Keyword(s):  
Relaxation Time ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Normal Subjects ◽  
Left Ventricular ◽  
Double Blind ◽  
Isovolumic Relaxation Time ◽  
Isovolumic Relaxation

1. Elevated plasma concentrations of brain natriuretic peptide are found in conditions associated with impaired left ventricular diastolic function. The purpose of this study was to determine whether this peptide actually plays a physiological role in improving myocardial performance in diastole. 2. Nine normal subjects received infusions of brain natriuretic peptide or placebo in a randomized, double-blind, crossover study. Brain natriuretic peptide infusion produced a significant reduction in isovolumic relaxation time (means and 95% confidence interval for difference−10.8 ms, −14.5 to −7.0 ms) (P < 0.01) and significantly increased both the peak E/A velocity (0.54, 0.14–0.94) (P < 0.05) and the E/A time velocity integral (1.09, 0.20–1.98) (P < 0.05). 3. These responses were evident at concentrations of brain natriuretic peptide that produced no associated effects on blood pressure, heart rate or stroke distance. 4. Brain natriuretic peptide infusion in normal subjects significantly reduces isovolumic relaxation time and improves transmitral Doppler flow profiles, suggesting that this peptide may be important in the control of left ventricular diastolic relaxation in man.

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